Dosing scheme by cohort
| Cohort . | IVB, mg/m2 . | CIVI, mg/m2 . | Intrapatient dose escalation . | n . |
|---|---|---|---|---|
| 1 | 30 | 30 | 20 | |
| 2 | 40 | 40 | 3 | |
| 3 | 30 | 30 | 19 | |
| 30 | 50 | Dose 5 (cycle 2, day 1) | (14 of 19) | |
| 4 | 30 | 30 | 16 | |
| 30 | 50 | Dose 2 (cycle 1, day 8) | (14 of 16) |
| Cohort . | IVB, mg/m2 . | CIVI, mg/m2 . | Intrapatient dose escalation . | n . |
|---|---|---|---|---|
| 1 | 30 | 30 | 20 | |
| 2 | 40 | 40 | 3 | |
| 3 | 30 | 30 | 19 | |
| 30 | 50 | Dose 5 (cycle 2, day 1) | (14 of 19) | |
| 4 | 30 | 30 | 16 | |
| 30 | 50 | Dose 2 (cycle 1, day 8) | (14 of 16) |
IVB indicates 30-minute intravenous bolus dose; CIVI, 4-hour continuous intravenous infusion; and n, number of patients receiving the specified dose.