Severe toxicities (grades 3 and 4) experienced by patients in cohort 4 (n = 16)
| . | No. of patients with toxicities . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| ANC | 16 | |
| WBC | 7 | 4 |
| Platelets | 4 | 3 |
| Hemorrhage* | 1 | |
| Cardiac | ||
| Hypotension | 1 | |
| Ventricular arrhythmia | 1 | |
| Cardiac-ischemia/infraction | 1 | |
| Respiratory | ||
| Hypoxia | 2 | 1 |
| GI/Hepatic | ||
| Diarrhea | 12 | |
| Abdominal pain/cramping | 1 | |
| AST or ALT | 3 | |
| Bilirubin | 1 | |
| Renal† | ||
| Renal failure | 1 | |
| CNS | ||
| Dysphagia | 1 | |
| Myalgia | 1 | |
| Pain | 1 | |
| Pruritus | 1 | |
| Possible infection | ||
| Febrile neutropenia | 4 | |
| Infection w/neutropenia | 6 | |
| Other | ||
| Fatigue | 2 | |
| Biochemical tumor lysis | 7 | |
| Erectile dysfunction | 1 | |
| Nausea | 3 | |
| . | No. of patients with toxicities . | |
|---|---|---|
| Grade 3 . | Grade 4 . | |
| Hematologic | ||
| ANC | 16 | |
| WBC | 7 | 4 |
| Platelets | 4 | 3 |
| Hemorrhage* | 1 | |
| Cardiac | ||
| Hypotension | 1 | |
| Ventricular arrhythmia | 1 | |
| Cardiac-ischemia/infraction | 1 | |
| Respiratory | ||
| Hypoxia | 2 | 1 |
| GI/Hepatic | ||
| Diarrhea | 12 | |
| Abdominal pain/cramping | 1 | |
| AST or ALT | 3 | |
| Bilirubin | 1 | |
| Renal† | ||
| Renal failure | 1 | |
| CNS | ||
| Dysphagia | 1 | |
| Myalgia | 1 | |
| Pain | 1 | |
| Pruritus | 1 | |
| Possible infection | ||
| Febrile neutropenia | 4 | |
| Infection w/neutropenia | 6 | |
| Other | ||
| Fatigue | 2 | |
| Biochemical tumor lysis | 7 | |
| Erectile dysfunction | 1 | |
| Nausea | 3 | |