Table 6 Mean AUC 0-∞ (log-linear... | American Society of Hematology

Table 6

Mean AUC_0-∞ (log-linear estimations) by cohort and dose level

Cohort	AUC_0-∞, mean ± SD (μM × h)	Patients	Dose level, mg/m²	AUC_0-∞, mean ± SD (μM × h)	Profiles
1	10.0 ± 5.6	20	30 + 30	10.4 ± 4.6	55
	(9.0 ± 2.9)*	(19)		(10.0 ± 3.7)*	(54)
2	9.0	2	40 + 40	9.0	2
3	11.4 ± 3.9	19	30 + 50	12.9 ± 3.7†	28
4	12.1 ± 2.4	16

Cohort	AUC_0-∞, mean ± SD (μM × h)	Patients	Dose level, mg/m²	AUC_0-∞, mean ± SD (μM × h)	Profiles
1	10.0 ± 5.6	20	30 + 30	10.4 ± 4.6	55
	(9.0 ± 2.9)*	(19)		(10.0 ± 3.7)*	(54)
2	9.0	2	40 + 40	9.0	2
3	11.4 ± 3.9	19	30 + 50	12.9 ± 3.7†	28
4	12.1 ± 2.4	16

Data for cohorts includes initial and escalated doses for all 58 patients (including re-enrolled patients).

Means without the outlier patient 6.

Comparison of AUC_0-∞ for all 30+30 and 30+50 doses, P = .002.