Grade 3 and higher adverse events
| . | Grade 3, no. . | Grade 4, no. . | Grade 5, no. . | Total, no. . |
|---|---|---|---|---|
| Hematologic adverse events | ||||
| Anemia | 9 | 1 | — | 10 |
| Thrombocytopenia | 5 | 11 | — | 16 |
| Neutropenia | 10 | 4 | — | 14 |
| Leukopenia | 11 | 3 | — | 14 |
| Nonhematologic adverse events | ||||
| Gastrointestinal | — | — | — | |
| Dyspepsia | 1 | — | — | 1 |
| Constipation | 2 | — | — | 2 |
| Nausea | 1 | — | — | 1 |
| Decreased appetite | 2 | — | — | 2 |
| Diarrhea | 1 | — | — | 1 |
| Diverticular abscess, perforated colon, abdominal abscess | 4 | — | — | 4 |
| Dehydration | 1 | — | — | 1 |
| Metabolic | ||||
| Hypocalcemia | 3 | — | — | 3 |
| Hyperglycemia | — | 2 | — | 2 |
| Hyponatremia | — | 1 | — | 1 |
| Constitutional | ||||
| Insomnia | 1 | — | — | 1 |
| Generalized weakness | 2 | — | — | 2 |
| Neurologic | ||||
| Neuromood | 3 | — | — | 3 |
| Tremor | 3 | — | — | 3 |
| Syncope | 2 | — | — | 2 |
| Steroid-induced psychosis | 1 | — | — | 1 |
| Mood swings | 2 | — | — | 2 |
| Depression | 1 | — | — | 1 |
| Vascular | ||||
| Edema | 2 | — | — | 2 |
| Thrombosis | 6 | 1 | — | 7 |
| Pulmonary embolism | 1 | — | 1 | 2 |
| Musculoskeletal | ||||
| Muscle spasms/cramps | 1 | — | — | 1 |
| Myopathy | 7 | 1 | — | 8 |
| Muscle weakness | 1 | — | — | 1 |
| Dermatology/skin | ||||
| Rash | 4 | — | — | 4 |
| Basal cell carcinoma | 1 | — | — | 1 |
| Ocular/visual: blurry vision | 1 | — | — | 1 |
| Cardiac: myocardial infarction | — | 1 | — | 1 |
| Renal/genitourinary | ||||
| Hematuria | 1 | — | — | 1 |
| Renal failure | 1 | 1 | — | 2 |
| Pulmonary/upper respiratory | ||||
| Dyspnea | 1 | — | — | 1 |
| Pneumonia | 1 | — | — | 1 |
| Infection | ||||
| Sepsis | 1 | — | — | 1 |
| Neutropenic fever | 1 | — | — | 1 |
| Staphylococcus infection | 1 | — | — | 1 |
| . | Grade 3, no. . | Grade 4, no. . | Grade 5, no. . | Total, no. . |
|---|---|---|---|---|
| Hematologic adverse events | ||||
| Anemia | 9 | 1 | — | 10 |
| Thrombocytopenia | 5 | 11 | — | 16 |
| Neutropenia | 10 | 4 | — | 14 |
| Leukopenia | 11 | 3 | — | 14 |
| Nonhematologic adverse events | ||||
| Gastrointestinal | — | — | — | |
| Dyspepsia | 1 | — | — | 1 |
| Constipation | 2 | — | — | 2 |
| Nausea | 1 | — | — | 1 |
| Decreased appetite | 2 | — | — | 2 |
| Diarrhea | 1 | — | — | 1 |
| Diverticular abscess, perforated colon, abdominal abscess | 4 | — | — | 4 |
| Dehydration | 1 | — | — | 1 |
| Metabolic | ||||
| Hypocalcemia | 3 | — | — | 3 |
| Hyperglycemia | — | 2 | — | 2 |
| Hyponatremia | — | 1 | — | 1 |
| Constitutional | ||||
| Insomnia | 1 | — | — | 1 |
| Generalized weakness | 2 | — | — | 2 |
| Neurologic | ||||
| Neuromood | 3 | — | — | 3 |
| Tremor | 3 | — | — | 3 |
| Syncope | 2 | — | — | 2 |
| Steroid-induced psychosis | 1 | — | — | 1 |
| Mood swings | 2 | — | — | 2 |
| Depression | 1 | — | — | 1 |
| Vascular | ||||
| Edema | 2 | — | — | 2 |
| Thrombosis | 6 | 1 | — | 7 |
| Pulmonary embolism | 1 | — | 1 | 2 |
| Musculoskeletal | ||||
| Muscle spasms/cramps | 1 | — | — | 1 |
| Myopathy | 7 | 1 | — | 8 |
| Muscle weakness | 1 | — | — | 1 |
| Dermatology/skin | ||||
| Rash | 4 | — | — | 4 |
| Basal cell carcinoma | 1 | — | — | 1 |
| Ocular/visual: blurry vision | 1 | — | — | 1 |
| Cardiac: myocardial infarction | — | 1 | — | 1 |
| Renal/genitourinary | ||||
| Hematuria | 1 | — | — | 1 |
| Renal failure | 1 | 1 | — | 2 |
| Pulmonary/upper respiratory | ||||
| Dyspnea | 1 | — | — | 1 |
| Pneumonia | 1 | — | — | 1 |
| Infection | ||||
| Sepsis | 1 | — | — | 1 |
| Neutropenic fever | 1 | — | — | 1 |
| Staphylococcus infection | 1 | — | — | 1 |
The higher grade is reported as the maximum grade for each patient.
— indicates not applicable.