Multivariate analysis in patients receiving tandem auto/alloHCT
| . | NRM . | Relapse . | Overall survival . | Progression-free survival . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| B2M > 3.5 mg/mL at diagnosis | 0.93 (0.3-3.1) | .90 | 2.51 (1.3-5.0) | .008 | 2.53 (1.1-5.8) | .03 | 1.87 (1.0-3.3) | .04 |
| First therapy–autoHCT > 10 mo | 2.01 (0.5-8.5) | .34 | 2.48 (1.0-6.1) | .05 | 3.13 (1.2-8.3) | .02 | 2.25 (1.1-4.8) | .03 |
| < PR at alloHCT | 1.25 (0.3-4.9) | .75 | 1.88 (0.8-4.2) | .13 | 2.00 (0.9-4.7) | .11 | 1.65 (0.8-3.3) | .15 |
| > 1 Prior induction therapy line | 0.43 (0.1-2.3) | .32 | 1.04 (0.5-2.4) | .93 | 0.75 (0.3-2.0) | .57 | 0.84 (0.4-1.8) | .65 |
| KS < 90% at alloHCT | 2.98 (0.6-15) | .18 | 2.94 (1.3-6.8) | .01 | 2.67 (0.9-8.1) | .08 | 2.92 (1.4-6.1) | .005 |
| Grade II-IV acute GVHD* | 6.51 (1.4-30) | .02 | 0.92 (0.5-1.8) | .81 | 1.93 (0.9-4.2) | .10 | 1.39 (0.8-2.5) | .26 |
| . | NRM . | Relapse . | Overall survival . | Progression-free survival . | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| B2M > 3.5 mg/mL at diagnosis | 0.93 (0.3-3.1) | .90 | 2.51 (1.3-5.0) | .008 | 2.53 (1.1-5.8) | .03 | 1.87 (1.0-3.3) | .04 |
| First therapy–autoHCT > 10 mo | 2.01 (0.5-8.5) | .34 | 2.48 (1.0-6.1) | .05 | 3.13 (1.2-8.3) | .02 | 2.25 (1.1-4.8) | .03 |
| < PR at alloHCT | 1.25 (0.3-4.9) | .75 | 1.88 (0.8-4.2) | .13 | 2.00 (0.9-4.7) | .11 | 1.65 (0.8-3.3) | .15 |
| > 1 Prior induction therapy line | 0.43 (0.1-2.3) | .32 | 1.04 (0.5-2.4) | .93 | 0.75 (0.3-2.0) | .57 | 0.84 (0.4-1.8) | .65 |
| KS < 90% at alloHCT | 2.98 (0.6-15) | .18 | 2.94 (1.3-6.8) | .01 | 2.67 (0.9-8.1) | .08 | 2.92 (1.4-6.1) | .005 |
| Grade II-IV acute GVHD* | 6.51 (1.4-30) | .02 | 0.92 (0.5-1.8) | .81 | 1.93 (0.9-4.2) | .10 | 1.39 (0.8-2.5) | .26 |
CI indicates confidence interval; and B2M, β-2-microglobulin.
Acute GVHD was considered a time-dependent covariate.