Table 3 Gene polymorphisms in the... | American Society of Hematology

Table 3

Gene polymorphisms in the Hodgkin's lymphoma patients and in control subjects

Gene	Genotype/phenotype	Hodgkin patients		Controls		P†
Gene	Genotype/phenotype	N	%	N	%	P†
UGT1A1	Missing or rare*	4		6		.18
	66	148	48	71	39
	67	130	42	89	49
	77	31	10	21	12
CYP3A4	Missing	3		3		1.00
	AA	278	90	166	90
	AG	29	9	17	9
	GG	3	1	1	1
GTPIE5	Missing	2		0		.99
	AA	130	42	79	42
	AG	141	45	85	45
	GG	40	13	23	12
GTT1	Missing	1		3		.67
	0	48	15	31	17
	1	264	85	153	83
GSTM1	Missing	1		3		.35
	0	164	53	105	57
	1	148	47	79	43

Gene	Genotype/phenotype	Hodgkin patients		Controls		P†
Gene	Genotype/phenotype	N	%	N	%	P†
UGT1A1	Missing or rare*	4		6		.18
	66	148	48	71	39
	67	130	42	89	49
	77	31	10	21	12
CYP3A4	Missing	3		3		1.00
	AA	278	90	166	90
	AG	29	9	17	9
	GG	3	1	1	1
GTPIE5	Missing	2		0		.99
	AA	130	42	79	42
	AG	141	45	85	45
	GG	40	13	23	12
GTT1	Missing	1		3		.67
	0	48	15	31	17
	1	264	85	153	83
GSTM1	Missing	1		3		.35
	0	164	53	105	57
	1	148	47	79	43

Patients with rare or missing phenotypes were not included in the prognostic analyses. For GSTT1 and GSTM1, genotype is not available; the information 0 or 1 refers to the presence or the absence of gene expression.

Two missing and 2 rare phenotypes for UGT1A1 (1 phenotype 65, and 1 phenotype 75) in HD patients, 3 missing and 2 rare phenotypes (2 phenotypes 65, and 1 phenotype 86) in controls.

†

Comparison of the proportions of between Hodgkin patients and controls, Fisher exact test, patients with missing or rare genotypes/phenotypes excluded.

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