Table 3

Genes differentially expressed 2-fold or greater in the FLT3-TKD signature

Gene symbolDescriptionFold change
Overexpressed in FLT3-TKD patients  TKD/WT 
    VNN1* Vanin 1 5.64 
    TREM1 Triggering receptor expressed on myeloid cells 1 4.87 
    HOXB6 Homeobox B6 4.34 
    CACNA2D4* Calcium channel, voltage-dependent, α2/Δ subunit 4 4.07 
    VNN2 Vanin 2 3.67 
    C3AR1 Complement component 3a receptor 1 3.62 
    EPB41L3* Erythrocyte membrane protein band 4.1-like 3 3.42 
    EVI2A Ecotropic viral integration site 2A 3.02 
    PKM2 Pyruvate kinase, muscle 2.95 
    OSCAR Osteoclast-associated receptor 2.92 
    ITGAX Integrin, αX (complement component 3 receptor 4 subunit) 2.91 
    CD93 CD93 molecule 2.87 
    GNS* Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) 2.82 
    UPB1 Ureidopropionase, β 2.81 
    ADAM8* ADAM metallopeptidase domain 8 2.70 
    SLC16A3* Solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 2.50 
    CD300LB CD300 molecule-like family member b 2.45 
    MYO1G Myosin IG 2.43 
    HAVCR2 Hepatitis A virus cellular receptor 2 2.40 
    ARHGEF3 ρ guanine nucleotide exchange factor (GEF) 3 2.32 
    MMP19 Matrix metallopeptidase 19; similar to matrix metalloproteinase-19 precursor (MMP-19) (matrix metalloproteinase RASI) (MMP-18) 2.29 
    PTPN6 Protein tyrosine phosphatase, non-receptor type 6 2.26 
    CD300A* CD300a molecule 2.24 
    CARD14 Caspase recruitment domain family, member 14 2.23 
    TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.22 
    CD300C CD300c molecule 2.12 
    ACSL4 Acyl-CoA synthetase long-chain family member 4 2.11 
    SLC11A1* Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 2.11 
    LFNG Lunatic fringe homolog (Drosophila) 2.09 
    CTSD Cathepsin D (lysosomal aspartyl peptidase) 2.09 
    CSF2RA Colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage) 2.08 
    TNFRSF1A Tumor necrosis factor receptor superfamily, member 1A 2.05 
    ST8SIA4 ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 2.05 
    F12 Coagulation factor XII (Hageman factor) 2.03 
    PSCA Prostate stem cell antigen 2.01 
Underexpressed in FLT3-TKD patients  WT/TKD 
    GYPA Glycophorin A (MNS blood group) 5.75 
    ERAF Erythroid associated factor 5.49 
    HEMGN Hemogen 5.41 
    MPO* Myeloperoxidase 5.31 
    XK X-linked Kx blood group (McLeod syndrome) 5.24 
    IL8 Interleukin 8 5.15 
    ALAS2 Aminolevulinate, Δ-, synthase 2 (sideroblastic/hypochromic anemia) 5.05 
    EPB42 Erythrocyte membrane protein band 4.2 4.42 
    PRDX2* Peroxiredoxin 2 3.98 
    C1QTNF4 C1q and tumor necrosis factor-related protein 4 3.73 
    HBA1; HBA2* Hemoglobin, α1; hemoglobin, α2 3.52 
    ADD2 Adducin 2(β) 3.34 
    HBA1 Hemoglobin, α1 3.34 
    PIP5K1B Phosphatidylinositol-4-phosphate 5-kinase, type I, β 3.33 
    GYPC Glycophorin C (Gerbich blood group) 3.32 
    MLLT3* Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to 3 3.26 
    KLF1 Kruppel-like factor 1 (erythroid) 3.11 
    GPR125 G protein-coupled receptor 125 3.01 
    GFI1B Growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) 2.79 
    RHOH ras homolog gene family, member H 2.76 
    KEL Kell blood group, metalloendopeptidase 2.75 
    BPGM 2,3-bisphosphoglycerate mutase 2.68 
    FECH Ferrochelatase (protoporphyria) 2.42 
    FAM46C Family with sequence similarity 46, member C 2.31 
    PAIP1* Poly(A) binding protein interacting protein 1 2.26 
    PRKD3* Protein kinase D3 2.23 
    MLF1IP MLF1 interacting protein 2.16 
    PGM2L1 Phosphoglucomutase 2-like 1 2.11 
    MGC4172 Short-chain dehydrogenase/reductase 2.08 
    EGFL8; LOC653870 EGF-like-domain, multiple 8; similar to palmitoyl-protein thioesterase 2 2.07 
    TSPAN5 Tetraspanin 5 2.07 
Gene symbolDescriptionFold change
Overexpressed in FLT3-TKD patients  TKD/WT 
    VNN1* Vanin 1 5.64 
    TREM1 Triggering receptor expressed on myeloid cells 1 4.87 
    HOXB6 Homeobox B6 4.34 
    CACNA2D4* Calcium channel, voltage-dependent, α2/Δ subunit 4 4.07 
    VNN2 Vanin 2 3.67 
    C3AR1 Complement component 3a receptor 1 3.62 
    EPB41L3* Erythrocyte membrane protein band 4.1-like 3 3.42 
    EVI2A Ecotropic viral integration site 2A 3.02 
    PKM2 Pyruvate kinase, muscle 2.95 
    OSCAR Osteoclast-associated receptor 2.92 
    ITGAX Integrin, αX (complement component 3 receptor 4 subunit) 2.91 
    CD93 CD93 molecule 2.87 
    GNS* Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) 2.82 
    UPB1 Ureidopropionase, β 2.81 
    ADAM8* ADAM metallopeptidase domain 8 2.70 
    SLC16A3* Solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 2.50 
    CD300LB CD300 molecule-like family member b 2.45 
    MYO1G Myosin IG 2.43 
    HAVCR2 Hepatitis A virus cellular receptor 2 2.40 
    ARHGEF3 ρ guanine nucleotide exchange factor (GEF) 3 2.32 
    MMP19 Matrix metallopeptidase 19; similar to matrix metalloproteinase-19 precursor (MMP-19) (matrix metalloproteinase RASI) (MMP-18) 2.29 
    PTPN6 Protein tyrosine phosphatase, non-receptor type 6 2.26 
    CD300A* CD300a molecule 2.24 
    CARD14 Caspase recruitment domain family, member 14 2.23 
    TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.22 
    CD300C CD300c molecule 2.12 
    ACSL4 Acyl-CoA synthetase long-chain family member 4 2.11 
    SLC11A1* Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 2.11 
    LFNG Lunatic fringe homolog (Drosophila) 2.09 
    CTSD Cathepsin D (lysosomal aspartyl peptidase) 2.09 
    CSF2RA Colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage) 2.08 
    TNFRSF1A Tumor necrosis factor receptor superfamily, member 1A 2.05 
    ST8SIA4 ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 2.05 
    F12 Coagulation factor XII (Hageman factor) 2.03 
    PSCA Prostate stem cell antigen 2.01 
Underexpressed in FLT3-TKD patients  WT/TKD 
    GYPA Glycophorin A (MNS blood group) 5.75 
    ERAF Erythroid associated factor 5.49 
    HEMGN Hemogen 5.41 
    MPO* Myeloperoxidase 5.31 
    XK X-linked Kx blood group (McLeod syndrome) 5.24 
    IL8 Interleukin 8 5.15 
    ALAS2 Aminolevulinate, Δ-, synthase 2 (sideroblastic/hypochromic anemia) 5.05 
    EPB42 Erythrocyte membrane protein band 4.2 4.42 
    PRDX2* Peroxiredoxin 2 3.98 
    C1QTNF4 C1q and tumor necrosis factor-related protein 4 3.73 
    HBA1; HBA2* Hemoglobin, α1; hemoglobin, α2 3.52 
    ADD2 Adducin 2(β) 3.34 
    HBA1 Hemoglobin, α1 3.34 
    PIP5K1B Phosphatidylinositol-4-phosphate 5-kinase, type I, β 3.33 
    GYPC Glycophorin C (Gerbich blood group) 3.32 
    MLLT3* Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to 3 3.26 
    KLF1 Kruppel-like factor 1 (erythroid) 3.11 
    GPR125 G protein-coupled receptor 125 3.01 
    GFI1B Growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) 2.79 
    RHOH ras homolog gene family, member H 2.76 
    KEL Kell blood group, metalloendopeptidase 2.75 
    BPGM 2,3-bisphosphoglycerate mutase 2.68 
    FECH Ferrochelatase (protoporphyria) 2.42 
    FAM46C Family with sequence similarity 46, member C 2.31 
    PAIP1* Poly(A) binding protein interacting protein 1 2.26 
    PRKD3* Protein kinase D3 2.23 
    MLF1IP MLF1 interacting protein 2.16 
    PGM2L1 Phosphoglucomutase 2-like 1 2.11 
    MGC4172 Short-chain dehydrogenase/reductase 2.08 
    EGFL8; LOC653870 EGF-like-domain, multiple 8; similar to palmitoyl-protein thioesterase 2 2.07 
    TSPAN5 Tetraspanin 5 2.07 
*

The gene was represented by multiple probe sets in the identified signature. The displayed fold change is the average (geometric mean) of all the probe sets for the gene.

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