Characteristics of patients with malignant mesothelioma after treatment for HL
| Patient no. . | Sex . | Age at HL treatment, y . | Treatment for HL . | RT dose, cGy . | HL to MM, y . | Localization of MM . | Age at MM, y . | Histology of MM . | Asbestos exposure* . | Survival, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 24.9 | Thoracic and abdominal RT + CT | 40 | 27.9 | Right pleura | 52.8 | Epithelial | Occupational | 20.5 |
| 2 | M | 33.1 | Abdominal RT + CT | 35‡ | 10.5 | Right pleura | 43.6 | Epithelial | No | 4.4 |
| 3† | M | 22.1 | Thoracic RT + CT | 25 | 18.9 | Right pleura | 40.9 | Epithelial | Occupational | 21.9 |
| 4 | F | 33.2 | Thoracic RT + CT | 40 | 32.9 | Left pleura | 66.2 | Mixed | No | 10.2 |
| 5† | F | 15.4 | Thoracic RT | 40 | 33.9 | Right pleura | 49.3 | Epithelial | No | 10.7 |
| 6† | F | 21.8 | Thoracic and abdominal RT + CT | 40 | 18.2 | Left pleura | 40.0 | Epithelial | No | 7.3 |
| 7 | M | 24.8 | Thoracic and abdominal RT + CT | 30 | 31.7 | Left pleura | 56.4 | Epithelial | Occupational | 25.1 |
| 8 | M | 25.6 | Thoracic and abdominal RT + CT | 40 | 32.5 | Right pleura | 58.1 | Epithelial | Environmental | 5.3 |
| 9 | M | 37.5 | Thoracic RT + CT | 40 | 25.0 | Left pleura | 62.5 | Epithelial | Occupational | 5.2 |
| 10 | M | 42.5 | Thoracic and abdominal RT | 40 | 19.7 | Left pleura | 62.2 | Epithelial | Occupational | 5.9 |
| 11 | M | 38.7 | Thoracic and abdominal RT + CT | 40 | 19.5 | Right pleura | 58.2 | Epithelial | Occupational | 15.7 |
| 12 | F | 31.8 | Thoracic and abdominal RT + CT | 40 | 34.1 | Left pleura | 65.9 | Epithelial | No | 17.7 |
| 13 | F | 22.1 | Thoracic RT + CT | 40 | 27.7 | Left pleura | 49.8 | Epithelial | No | 1.7 |
| Patient no. . | Sex . | Age at HL treatment, y . | Treatment for HL . | RT dose, cGy . | HL to MM, y . | Localization of MM . | Age at MM, y . | Histology of MM . | Asbestos exposure* . | Survival, mo . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 24.9 | Thoracic and abdominal RT + CT | 40 | 27.9 | Right pleura | 52.8 | Epithelial | Occupational | 20.5 |
| 2 | M | 33.1 | Abdominal RT + CT | 35‡ | 10.5 | Right pleura | 43.6 | Epithelial | No | 4.4 |
| 3† | M | 22.1 | Thoracic RT + CT | 25 | 18.9 | Right pleura | 40.9 | Epithelial | Occupational | 21.9 |
| 4 | F | 33.2 | Thoracic RT + CT | 40 | 32.9 | Left pleura | 66.2 | Mixed | No | 10.2 |
| 5† | F | 15.4 | Thoracic RT | 40 | 33.9 | Right pleura | 49.3 | Epithelial | No | 10.7 |
| 6† | F | 21.8 | Thoracic and abdominal RT + CT | 40 | 18.2 | Left pleura | 40.0 | Epithelial | No | 7.3 |
| 7 | M | 24.8 | Thoracic and abdominal RT + CT | 30 | 31.7 | Left pleura | 56.4 | Epithelial | Occupational | 25.1 |
| 8 | M | 25.6 | Thoracic and abdominal RT + CT | 40 | 32.5 | Right pleura | 58.1 | Epithelial | Environmental | 5.3 |
| 9 | M | 37.5 | Thoracic RT + CT | 40 | 25.0 | Left pleura | 62.5 | Epithelial | Occupational | 5.2 |
| 10 | M | 42.5 | Thoracic and abdominal RT | 40 | 19.7 | Left pleura | 62.2 | Epithelial | Occupational | 5.9 |
| 11 | M | 38.7 | Thoracic and abdominal RT + CT | 40 | 19.5 | Right pleura | 58.2 | Epithelial | Occupational | 15.7 |
| 12 | F | 31.8 | Thoracic and abdominal RT + CT | 40 | 34.1 | Left pleura | 65.9 | Epithelial | No | 17.7 |
| 13 | F | 22.1 | Thoracic RT + CT | 40 | 27.7 | Left pleura | 49.8 | Epithelial | No | 1.7 |
HL indicates Hodgkin lymphoma; M, male; F, female; RT, radiotherapy; MM, malignant mesothelioma; and CT, chemotherapy.
In The Netherlands, there is no exposure to endemic asbestos.
Patient who developed another second primary malignancy after HL. Patient 3 had thoracic sarcoma treated with surgery 17 years after HL; patient 5 had breast carcinoma treated with chemotherapy 20 years after HL; and patient 6 had thyroid carcinoma treated with iodine 8 years after HL.
Patient was not irradiated to the chest.