Functional profiles of HHV-8–specific CD8+ T cells in MCD patients and AC
Patient . | Peptide stimulation . | Functions of HHV-8–specific CD8+ T cells* . | HHV-8 viral load (copies/1.5 105 PBMC) . | CD4 cell count/mm3 . | |||||
---|---|---|---|---|---|---|---|---|---|
IFN-γ+ . | IL-2+ . | TNF-α+ . | CD107a+ . | MIP1β+ . | Number of functions† . | ||||
MCD REP | None | 0.01 | 0.12 | 0.01 | 0.16 | 0.09 | |||
K15 pools, GpH59-68, GpB492-500 | 0.21 | 0.10 | 0.03 | 0.15 | 0.12 | ||||
Δ | 0.20 | 0.00 | 0.02 | 0.00 | 0.00 | 1 | 837 | 305 | |
MCD NEG | None | 0.15 | 0.06 | 0.03 | 0.16 | 0.56 | |||
GpH59-68, GpB492-500 | 1.54 | 0.09 | 0.18 | 0.21 | 1.30 | ||||
Δ | 1.39 | 0.03 | 0.15 | 0.05 | 0.74 | 3 | 240 | 34 | |
MCD UAG | None | 0.02 | 0.13 | 0.02 | 0.40 | 0.53 | |||
K1231-45, K15166-180 | 0.50 | 0.10 | 0.43 | 0.84 | 1.23 | ||||
Δ | 0.48 | 0.00 | 0.43 | 0.44 | 0.70 | 4 | 12 770 | 1789 | |
AC 210 | None | 0.06 | 0.28 | 0.02 | 0.99 | 0.21 | |||
K1231-45, GpH59-68, GpB492-500 | 0.44 | 0.21 | 0.06 | 1.07 | 0.90 | ||||
Δ | 0.38 | 0.00 | 0.04 | 0.08 | 0.69 | 2 | <10 | 279 | |
AC 12001 | None | 0.01 | 0.03 | 0.07 | 0.13 | 0.26 | |||
K1231-45, LANA1116-1124 | 0.19 | 0.08 | 0.11 | 0.45 | 0.78 | ||||
Δ | 0.18 | 0.05 | 0.04 | 0.32 | 0.52 | 3 | <10 | 488 | |
AC 11007 | None | 0.12 | 0.19 | 0.11 | 0.80 | 1.28 | |||
GpH59-68, GpB492-500 | 1.45 | 0.17 | 0.86 | 1.63 | 3.44 | ||||
Δ | 1.33 | 0.00 | 0.75 | 0.83 | 2.16 | 4 | <10 | 709 | |
AC NAH | None | 0.06 | 0.12 | 0.06 | 0.43 | 0.76 | |||
GpH59-68, GpB492-500 | 0.44 | 0.17 | 0.33 | 0.95 | 1.67 | ||||
Δ | 0.38 | 0.05 | 0.27 | 0.52 | 0.91 | 4 | <10 | 361 |
Patient . | Peptide stimulation . | Functions of HHV-8–specific CD8+ T cells* . | HHV-8 viral load (copies/1.5 105 PBMC) . | CD4 cell count/mm3 . | |||||
---|---|---|---|---|---|---|---|---|---|
IFN-γ+ . | IL-2+ . | TNF-α+ . | CD107a+ . | MIP1β+ . | Number of functions† . | ||||
MCD REP | None | 0.01 | 0.12 | 0.01 | 0.16 | 0.09 | |||
K15 pools, GpH59-68, GpB492-500 | 0.21 | 0.10 | 0.03 | 0.15 | 0.12 | ||||
Δ | 0.20 | 0.00 | 0.02 | 0.00 | 0.00 | 1 | 837 | 305 | |
MCD NEG | None | 0.15 | 0.06 | 0.03 | 0.16 | 0.56 | |||
GpH59-68, GpB492-500 | 1.54 | 0.09 | 0.18 | 0.21 | 1.30 | ||||
Δ | 1.39 | 0.03 | 0.15 | 0.05 | 0.74 | 3 | 240 | 34 | |
MCD UAG | None | 0.02 | 0.13 | 0.02 | 0.40 | 0.53 | |||
K1231-45, K15166-180 | 0.50 | 0.10 | 0.43 | 0.84 | 1.23 | ||||
Δ | 0.48 | 0.00 | 0.43 | 0.44 | 0.70 | 4 | 12 770 | 1789 | |
AC 210 | None | 0.06 | 0.28 | 0.02 | 0.99 | 0.21 | |||
K1231-45, GpH59-68, GpB492-500 | 0.44 | 0.21 | 0.06 | 1.07 | 0.90 | ||||
Δ | 0.38 | 0.00 | 0.04 | 0.08 | 0.69 | 2 | <10 | 279 | |
AC 12001 | None | 0.01 | 0.03 | 0.07 | 0.13 | 0.26 | |||
K1231-45, LANA1116-1124 | 0.19 | 0.08 | 0.11 | 0.45 | 0.78 | ||||
Δ | 0.18 | 0.05 | 0.04 | 0.32 | 0.52 | 3 | <10 | 488 | |
AC 11007 | None | 0.12 | 0.19 | 0.11 | 0.80 | 1.28 | |||
GpH59-68, GpB492-500 | 1.45 | 0.17 | 0.86 | 1.63 | 3.44 | ||||
Δ | 1.33 | 0.00 | 0.75 | 0.83 | 2.16 | 4 | <10 | 709 | |
AC NAH | None | 0.06 | 0.12 | 0.06 | 0.43 | 0.76 | |||
GpH59-68, GpB492-500 | 0.44 | 0.17 | 0.33 | 0.95 | 1.67 | ||||
Δ | 0.38 | 0.05 | 0.27 | 0.52 | 0.91 | 4 | <10 | 361 |