Cytogenetic features in DS-AML versus non–DS-AML
| Cytogenetic features . | DS-AML, %, n = 135 . | Non–DS-AML, %, n = 703 . | P . | Cytogenetic features . | DS-AML, %, n = 135 . | Non–DS-AML, %, n = 703 . | P . |
|---|---|---|---|---|---|---|---|
| Number of anomalies | −X¶ | 3.2 | 5.4 | NS | |||
| 1 anomaly | 42 | 61 | −Y# | 1.4 | 11 | <.05 | |
| 2 anomalies | 25 | 20 | <.001 | dup(1q) | 16 | 2.0 | <.001 |
| 3 or more anomalies* | 33 | 19 | −5 | 1.5 | 0.3 | NS | |
| Ploidy level | del(5q) | 1.5 | 2.7 | NS | |||
| Hypodiploidy† | 5.2 | 16 | +6 | 0.7 | 4.4 | NS | |
| Pseudodiploidy‡ | 43 | 61 | del(6q) | 5.2 | 1.6 | <.05 | |
| Hyperdiploidy, low§ | 45 | 21 | <.001 | −7 | 2.2 | 6.3 | NS |
| Hyperdiploidy, high‖ | 4.4 | 1.7 | del(7p) | 10 | 1.7 | <.001 | |
| Triploidy | 0 | 0 | del(7q) | 0.7 | 4.0 | NS | |
| Tetraploidy | 2.2 | 0.1 | dup(7q) | 5.9 | 0.4 | <.001 | |
| Aberrations | +8 | 27 | 12 | <.001 | |||
| t(1;22)(p13;q13) | 0 | 2.1 | NS | +11 | 8.1 | 0.6 | <.001 |
| inv(3)(q21q26) | 0.7 | 0 | NS | del(11q) | 3.0 | 1.6 | NS |
| t(6;9)(p22;q34) | 0 | 0.6 | NS | del(13q) | 3.7 | 1.3 | NS |
| t(8;21)(q22;q22) | 0.7 | 11 | <.001 | del(16q) | 7.4 | 1.0 | <.001 |
| t(9;22)(q34;q11) | 0 | 0.7 | NS | del(17p) | 1.5 | 2.6 | NS |
| t(11q23) | 0 | 20 | <.001 | +19 | 7.4 | 7.0 | NS |
| t(15;17)(q22;q21) | 0.7 | 4.8 | NS | +21 | 23 | 9.0 | <.001 |
| inv(16)(p13q22) | 0 | 4.8 | <.05 | +22 | 5.2 | 2.7 | NS |
| Cytogenetic features . | DS-AML, %, n = 135 . | Non–DS-AML, %, n = 703 . | P . | Cytogenetic features . | DS-AML, %, n = 135 . | Non–DS-AML, %, n = 703 . | P . |
|---|---|---|---|---|---|---|---|
| Number of anomalies | −X¶ | 3.2 | 5.4 | NS | |||
| 1 anomaly | 42 | 61 | −Y# | 1.4 | 11 | <.05 | |
| 2 anomalies | 25 | 20 | <.001 | dup(1q) | 16 | 2.0 | <.001 |
| 3 or more anomalies* | 33 | 19 | −5 | 1.5 | 0.3 | NS | |
| Ploidy level | del(5q) | 1.5 | 2.7 | NS | |||
| Hypodiploidy† | 5.2 | 16 | +6 | 0.7 | 4.4 | NS | |
| Pseudodiploidy‡ | 43 | 61 | del(6q) | 5.2 | 1.6 | <.05 | |
| Hyperdiploidy, low§ | 45 | 21 | <.001 | −7 | 2.2 | 6.3 | NS |
| Hyperdiploidy, high‖ | 4.4 | 1.7 | del(7p) | 10 | 1.7 | <.001 | |
| Triploidy | 0 | 0 | del(7q) | 0.7 | 4.0 | NS | |
| Tetraploidy | 2.2 | 0.1 | dup(7q) | 5.9 | 0.4 | <.001 | |
| Aberrations | +8 | 27 | 12 | <.001 | |||
| t(1;22)(p13;q13) | 0 | 2.1 | NS | +11 | 8.1 | 0.6 | <.001 |
| inv(3)(q21q26) | 0.7 | 0 | NS | del(11q) | 3.0 | 1.6 | NS |
| t(6;9)(p22;q34) | 0 | 0.6 | NS | del(13q) | 3.7 | 1.3 | NS |
| t(8;21)(q22;q22) | 0.7 | 11 | <.001 | del(16q) | 7.4 | 1.0 | <.001 |
| t(9;22)(q34;q11) | 0 | 0.7 | NS | del(17p) | 1.5 | 2.6 | NS |
| t(11q23) | 0 | 20 | <.001 | +19 | 7.4 | 7.0 | NS |
| t(15;17)(q22;q21) | 0.7 | 4.8 | NS | +21 | 23 | 9.0 | <.001 |
| inv(16)(p13q22) | 0 | 4.8 | <.05 | +22 | 5.2 | 2.7 | NS |
AML indicates acute myeloid leukemia; DS, Down syndrome; and NS, not significant.
Includes also cases with “incomplete” karyotypes.
Less than 47 chromosomes in DS-AML.
Forty-seven chromosomes in DS-AML.
Forty-seven to 50 chromosomes in non–DS-AML; 48–50 chromosomes in DS-AML.
Fifty-one to 57 chromosomes.
Females only.
Males only.