Activity of HA22 and HA22-LR on six CD22-positive cell lines
| Cell line . | IC50 ± SE (ng/mL) . | Relative activity . | |
|---|---|---|---|
| HA22 . | HA22-LR . | ||
| CA46 (n = 5) | 0.30 ± 0.08 | 0.26 ± 0.06 | 1.15 |
| Daudi (n = 3) | 0.27 ± 0.04 | 0.24 ± 0.04 | 1.12 |
| Ramos (n = 3) | 1.62 ± 0.28 | 1.78 ± 0.15 | 0.91 |
| Raji* (n = 10) | 0.36 ± 0.04 | 0.73 ± 0.09 | 0.49 |
| KOPN-8* (n = 3) | 0.10 ± 0.02 | 0.45 ± 0.05 | 0.22 |
| WSU-CLL* (n = 4) | 2.50 ± 0.53 | 1.18 ± 0.34 | 2.12 |
| Cell line . | IC50 ± SE (ng/mL) . | Relative activity . | |
|---|---|---|---|
| HA22 . | HA22-LR . | ||
| CA46 (n = 5) | 0.30 ± 0.08 | 0.26 ± 0.06 | 1.15 |
| Daudi (n = 3) | 0.27 ± 0.04 | 0.24 ± 0.04 | 1.12 |
| Ramos (n = 3) | 1.62 ± 0.28 | 1.78 ± 0.15 | 0.91 |
| Raji* (n = 10) | 0.36 ± 0.04 | 0.73 ± 0.09 | 0.49 |
| KOPN-8* (n = 3) | 0.10 ± 0.02 | 0.45 ± 0.05 | 0.22 |
| WSU-CLL* (n = 4) | 2.50 ± 0.53 | 1.18 ± 0.34 | 2.12 |
Significant difference (P < .05 in a paired, 2-tailed t test) between the IC50 values of HA22 and HA22-LR.