Table 2

Reactions of DDAbs 1-16 with wild-type (construct 1), truncated (construct 3), and mutant (constructs 4-6) GPIIIa

DDAbConstruct 1Construct 3Construct 4 A50S, R62Q, D66AConstruct 5 E52, 55AConstruct 6 S53ABlocked by AP3*
1 + + − + + + 
2 + + − + + + 
3 + + − + + + 
4 + + − + + + 
5 + + − + + + 
6 + + − + + + 
7 + + − + + + 
8 + + − − − + 
9 + + − − − + 
10 + + + − + + 
11 + + + − + + 
12 + + − − + − 
13 + + − + + − 
14 + + + − + − 
15 + − − − + − 
16 + − + + + − 
DDAbConstruct 1Construct 3Construct 4 A50S, R62Q, D66AConstruct 5 E52, 55AConstruct 6 S53ABlocked by AP3*
1 + + − + + + 
2 + + − + + + 
3 + + − + + + 
4 + + − + + + 
5 + + − + + + 
6 + + − + + + 
7 + + − + + + 
8 + + − − − + 
9 + + − − − + 
10 + + + − + + 
11 + + + − + + 
12 + + − − + − 
13 + + − + + − 
14 + + + − + − 
15 + − − − + − 
16 + − + + + − 

Reactions shown were obtained in the presence of quinine. No reactions were obtained in the absence of quinine.

+ indicates positive reaction; and −, no reaction.

*

Reactions with platelet GPIIIa blocked by monoclonal AP3.

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