v-Abl–mediated fetal liver transformation
| Genotype . | Number of embryos . | Embryos displaying transformation . |
|---|---|---|
| Pim-1-/-/Pim-2-/-/SOCS-1-/- | 11 | 4 |
| Pim-1-/-/Pim-2-/-/SOCS-1-/+ | 28 | 0 |
| Pim-1-/-/Pim-2-/-/SOCS-1+/+ | 9 | 0 |
| Total | 48 | 4 |
| Genotype . | Number of embryos . | Embryos displaying transformation . |
|---|---|---|
| Pim-1-/-/Pim-2-/-/SOCS-1-/- | 11 | 4 |
| Pim-1-/-/Pim-2-/-/SOCS-1-/+ | 28 | 0 |
| Pim-1-/-/Pim-2-/-/SOCS-1+/+ | 9 | 0 |
| Total | 48 | 4 |
Fetal liver–derived pre-B cells were infected with A-MuLV. v-Abl–mediated transformation was examined 2 weeks after infection. Embryos showing at least 2 wells exhibiting cytokine-independent growth in a 96-well plate were counted as positive.
P < .02 by Fisher's exact test