TP53 mutation frequency in published series of diffuse large B-cell lymphoma
| Collaborative groups (reference no.) . | TP53-mutation cases, n . | Total cases studied, n . | Mutation frequency, % . | Methods used . | Exons screened . | Missense mutation, % . |
|---|---|---|---|---|---|---|
| Japan: Drs A. Ichikawa and T. Kinoshita (29) | 14 | 64 | 21.9 | SSCP | 5-9 | 93 |
| United States (NY): Dr P.R. Koduru (30) | 18 | 84 | 21.4 | SSCP | 5-9 | 83 |
| Denmark: Dr M.B. Mφller (31) | 7 | 34 | 20.6 | DGGE | 2-11 | 100 |
| Spain: Drs M. Sanchez-Beato and M.A. Piris (33) | 14 | 62 | 22.6 | Sequencing | 4-8 | 93 |
| France: Drs K. Leroy, C. Haioun, and P. Gaullard (34) | 16 | 69 | 23.2 | DGGE | 5-8 | 88 |
| Brazil: Drs F.R. Kerbauy and G.W. Colleoni (36) | 9 | 51 | 17.6 | SSCP | 5-9 | 100 |
| LLMPP: Drs K.H. Young and T.C. Greiner (23) | 24 | 113 | 21.2 | dHPLC | 5-8 | 83 |
| Total | 102 | 477 | 21.4 | — | — | 91 |
| Collaborative groups (reference no.) . | TP53-mutation cases, n . | Total cases studied, n . | Mutation frequency, % . | Methods used . | Exons screened . | Missense mutation, % . |
|---|---|---|---|---|---|---|
| Japan: Drs A. Ichikawa and T. Kinoshita (29) | 14 | 64 | 21.9 | SSCP | 5-9 | 93 |
| United States (NY): Dr P.R. Koduru (30) | 18 | 84 | 21.4 | SSCP | 5-9 | 83 |
| Denmark: Dr M.B. Mφller (31) | 7 | 34 | 20.6 | DGGE | 2-11 | 100 |
| Spain: Drs M. Sanchez-Beato and M.A. Piris (33) | 14 | 62 | 22.6 | Sequencing | 4-8 | 93 |
| France: Drs K. Leroy, C. Haioun, and P. Gaullard (34) | 16 | 69 | 23.2 | DGGE | 5-8 | 88 |
| Brazil: Drs F.R. Kerbauy and G.W. Colleoni (36) | 9 | 51 | 17.6 | SSCP | 5-9 | 100 |
| LLMPP: Drs K.H. Young and T.C. Greiner (23) | 24 | 113 | 21.2 | dHPLC | 5-8 | 83 |
| Total | 102 | 477 | 21.4 | — | — | 91 |
SSCP indicates single-stranded conformation polymorphism; DGGE, denaturing gradient gel electrophoresis; LLMPP, Lymphoma and Leukemia Molecular Profiling Project; and dHPLC, denaturing high performance liquid chromatography.