Multivariate analysis of TP53 mutations in diffuse large B-cell lymphoma
| Variables . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| IPI score 3-5 | 2.2 | 1.4-3.5 | < .001 |
| All TP53 mutations | 1.7 | 1.1-2.8 | .021 |
| All TP53 DNA-binding domain mutations | 3.3 | 2.0-5.5 | < .001 |
| Loop-L2 mutations | 1.6 | 0.7-3.3 | .262 |
| Loop-L3 mutations | 2.3 | 1.2-4.6 | .017 |
| LSH domain mutations | 3.4 | 1.6-7.0 | .014 |
| Direct DNA contact mutations | 2.6 | 1.3-5.2 | .007 |
| Variables . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| IPI score 3-5 | 2.2 | 1.4-3.5 | < .001 |
| All TP53 mutations | 1.7 | 1.1-2.8 | .021 |
| All TP53 DNA-binding domain mutations | 3.3 | 2.0-5.5 | < .001 |
| Loop-L2 mutations | 1.6 | 0.7-3.3 | .262 |
| Loop-L3 mutations | 2.3 | 1.2-4.6 | .017 |
| LSH domain mutations | 3.4 | 1.6-7.0 | .014 |
| Direct DNA contact mutations | 2.6 | 1.3-5.2 | .007 |
LSH indicates loop-sheet-helix.