Comparison of the clinical features of patients with diffuse large B-cell lymphoma with TP53 mutations in 3 DNA-binding motifs versus patients with WT-TP53
| Clinical features . | WT-TP53 . | Loop-L2 mutations . | Loop-L3 mutations . | LSH domain mutations . |
|---|---|---|---|---|
| No. of cases | 190 | 19 | 23 | 20 |
| 5-y survival, % (P) | 45 | 40 (.718) | 19 (.087) | 0 (.002) |
| Median survival, y (P) | 4.5 | 1.2 (.154) | 1.0 (.012) | 1.0 (.002) |
| Complete remission, % (P) | 69 | 54 (.222) | 50 (.209) | 58 (.526) |
| Disease progression, % (P) | 12 | 13 (.692) | 33 (.051) | 17 (.641) |
| Clinical features . | WT-TP53 . | Loop-L2 mutations . | Loop-L3 mutations . | LSH domain mutations . |
|---|---|---|---|---|
| No. of cases | 190 | 19 | 23 | 20 |
| 5-y survival, % (P) | 45 | 40 (.718) | 19 (.087) | 0 (.002) |
| Median survival, y (P) | 4.5 | 1.2 (.154) | 1.0 (.012) | 1.0 (.002) |
| Complete remission, % (P) | 69 | 54 (.222) | 50 (.209) | 58 (.526) |
| Disease progression, % (P) | 12 | 13 (.692) | 33 (.051) | 17 (.641) |
WT, indicates wild-type; and LSH, Loop-Sheet-Helix.