Site of CNS involvement, initial response after study treatment, and type of CNS relapse
| Type of CNS involvement . | No. of patients . | Percent of all CNS relapse . | Response after end of therapy . | With concurrent systemic relapse (%) . | ||
|---|---|---|---|---|---|---|
| . | n . | % . | ||||
| Parenchymal | 38 | 65.5 | CR | 15 | 39.5 | 7 |
| PR | 4 | 10.5 | 3 | |||
| PD | 18 | 47.4 | 7 | |||
| Unknown | 1 | 2.6 | 1 | |||
| Meningeosis lymphomatosa | 15 | 25.9 | CR | 4 | 26.7 | |
| PD | 9 | 60.0 | 2 | |||
| TRD in PD | 2 | 13.3 | 2 | |||
| Parenchymal and meningeal | 5 | 8.6 | CR | 1 | 20.0 | 1 |
| PD | 3 | 60.0 | 1 | |||
| Unknown | 1 | 20.0 | ||||
| All | 58 | 100 | CR | 20 | 34.5 | |
| No CR | 38 | 65.5 | 24 (41.4%) | |||
| Type of CNS involvement . | No. of patients . | Percent of all CNS relapse . | Response after end of therapy . | With concurrent systemic relapse (%) . | ||
|---|---|---|---|---|---|---|
| . | n . | % . | ||||
| Parenchymal | 38 | 65.5 | CR | 15 | 39.5 | 7 |
| PR | 4 | 10.5 | 3 | |||
| PD | 18 | 47.4 | 7 | |||
| Unknown | 1 | 2.6 | 1 | |||
| Meningeosis lymphomatosa | 15 | 25.9 | CR | 4 | 26.7 | |
| PD | 9 | 60.0 | 2 | |||
| TRD in PD | 2 | 13.3 | 2 | |||
| Parenchymal and meningeal | 5 | 8.6 | CR | 1 | 20.0 | 1 |
| PD | 3 | 60.0 | 1 | |||
| Unknown | 1 | 20.0 | ||||
| All | 58 | 100 | CR | 20 | 34.5 | |
| No CR | 38 | 65.5 | 24 (41.4%) | |||
CNS indicates central nervous system; PR, partial remission; PD, progressive disease; and TRD, treatment-related death.