Patient characteristics at brain parenchyma relapse
| Characteristic . | Value . |
|---|---|
| Patients, no. | 113 |
| Patient age | |
| Median, y (range) | 65 (19-85) |
| 60 years or older | 70 (62) |
| Neurologic symptoms* | |
| Mental status changes | 43 (38) |
| Gait/balance disturbance | 29 (26) |
| Peripheral sensory/motor symptoms | 27 (24) |
| Headache | 23 (20) |
| Cranial nerve deficits/palsy | 19 (17) |
| Seizures | 7 (6) |
| Other† | 14 (12) |
| Not reported | 7 (6) |
| Diagnosis of brain relapse | |
| Brain imaging, no biopsy | 59 (52) |
| Brain imaging and biopsy | 54 (48) |
| ECOG performance status | |
| 0 | 6 (5) |
| 1 | 18 (16) |
| 2 | 27 (24) |
| 3 | 36 (32) |
| 4 | 8 (7) |
| Not reported | 18 (16) |
| No. of brain lesions | |
| 1 | 53 (47) |
| 2 or more | 56 (50) |
| Not reported | 4 (4) |
| Involvement of deep brain structures‡ | 45 (40) |
| Site of brain disease§ | |
| Cerebral hemisphere | 76 (67) |
| Basal ganglia | 15 (13) |
| Periventricular | 15 (13) |
| Cerebellum | 14 (12) |
| Brainstem | 13 (11) |
| Corpus callosum | 10 (9) |
| Meninges | 8 (7) |
| Not reported | 7 (6) |
| Cerebrospinal fluid cytology | |
| Negative for lymphoma cells | 56 (50) |
| Positive for lymphoma cells | 11 (10) |
| Not reported | 46 (40) |
| Characteristic . | Value . |
|---|---|
| Patients, no. | 113 |
| Patient age | |
| Median, y (range) | 65 (19-85) |
| 60 years or older | 70 (62) |
| Neurologic symptoms* | |
| Mental status changes | 43 (38) |
| Gait/balance disturbance | 29 (26) |
| Peripheral sensory/motor symptoms | 27 (24) |
| Headache | 23 (20) |
| Cranial nerve deficits/palsy | 19 (17) |
| Seizures | 7 (6) |
| Other† | 14 (12) |
| Not reported | 7 (6) |
| Diagnosis of brain relapse | |
| Brain imaging, no biopsy | 59 (52) |
| Brain imaging and biopsy | 54 (48) |
| ECOG performance status | |
| 0 | 6 (5) |
| 1 | 18 (16) |
| 2 | 27 (24) |
| 3 | 36 (32) |
| 4 | 8 (7) |
| Not reported | 18 (16) |
| No. of brain lesions | |
| 1 | 53 (47) |
| 2 or more | 56 (50) |
| Not reported | 4 (4) |
| Involvement of deep brain structures‡ | 45 (40) |
| Site of brain disease§ | |
| Cerebral hemisphere | 76 (67) |
| Basal ganglia | 15 (13) |
| Periventricular | 15 (13) |
| Cerebellum | 14 (12) |
| Brainstem | 13 (11) |
| Corpus callosum | 10 (9) |
| Meninges | 8 (7) |
| Not reported | 7 (6) |
| Cerebrospinal fluid cytology | |
| Negative for lymphoma cells | 56 (50) |
| Positive for lymphoma cells | 11 (10) |
| Not reported | 46 (40) |
Values indicate no. (%) of patients unless otherwise noted.
Some patients had multiple neurologic symptoms.
Other symptoms were aphasia (n = 4), nausea and vomiting (n = 4), urinary incontinence (n = 3), dizziness (n = 2), and back pain (n = 1).
Deep brain structures included basal ganglia, brainstem, corpus callosum, and cerebellum.
Some patients had involvement of multiple brain sites.