Multiple linear regression model for prediction of weekly warfarin dose
| Variable . | Partial regression coefficient . | P . | Partial R2 statistic, % . |
|---|---|---|---|
| Age, y | −0.0054 | 1.10−1 | 0.3 |
| INR/dose (first available) | −2.9909 | 3.10−8 | 4.9 |
| Weight, kg | 0.0157 | 3.10−5 | 2.7 |
| Therapeutic indication | 3.8 | ||
| Heart valve prosthesis | 0.5726 | 1.10−6 | |
| Thromboembolic disease | 0.4333 | 3.10−2 | |
| Simvastatin | −0.4442 | 10−2 | 1.0 |
| Amiodarone | −0.7748 | 10−9 | 5.9 |
| CYP2C9 *2/*3/*5/*11 | 5.7 | ||
| One variant allele | −0.5115 | 2.10−6 | |
| Two variant alleles | −1.1043 | 10−5 | |
| VKORC1 3673G>A | 20.1 | ||
| 3673GA | −0.8352 | 5.10−7 | |
| 3673AA | −1.6841 | <10−12 |
| Variable . | Partial regression coefficient . | P . | Partial R2 statistic, % . |
|---|---|---|---|
| Age, y | −0.0054 | 1.10−1 | 0.3 |
| INR/dose (first available) | −2.9909 | 3.10−8 | 4.9 |
| Weight, kg | 0.0157 | 3.10−5 | 2.7 |
| Therapeutic indication | 3.8 | ||
| Heart valve prosthesis | 0.5726 | 1.10−6 | |
| Thromboembolic disease | 0.4333 | 3.10−2 | |
| Simvastatin | −0.4442 | 10−2 | 1.0 |
| Amiodarone | −0.7748 | 10−9 | 5.9 |
| CYP2C9 *2/*3/*5/*11 | 5.7 | ||
| One variant allele | −0.5115 | 2.10−6 | |
| Two variant alleles | −1.1043 | 10−5 | |
| VKORC1 3673G>A | 20.1 | ||
| 3673GA | −0.8352 | 5.10−7 | |
| 3673AA | −1.6841 | <10−12 |
The partial R2 statistics measures the degree of association between 2 random variables, with the effect of a set of controlling random variables removed.