CRU of JAM-A+ KSL and KSL
| Cell dose injected . | No. negative . | No. analyzed . |
|---|---|---|
| JAM-A+KSL | ||
| 25 | 2 | 3 |
| 100 | 2 | 9 |
| 300 | 0 | 4 |
| CRU frequency | 1 in 64 (95% confidence interval: 1 in 45 to 1 in 92) | |
| KSL | ||
| 25 | 2 | 3 |
| 100 | 2 | 7 |
| 300 | 1 | 6 |
| 400 | 0 | 2 |
| CRU frequency | 1 in 109 (95% confidence interval: 1 in 77 to 1 in 154) | |
| Cell dose injected . | No. negative . | No. analyzed . |
|---|---|---|
| JAM-A+KSL | ||
| 25 | 2 | 3 |
| 100 | 2 | 9 |
| 300 | 0 | 4 |
| CRU frequency | 1 in 64 (95% confidence interval: 1 in 45 to 1 in 92) | |
| KSL | ||
| 25 | 2 | 3 |
| 100 | 2 | 7 |
| 300 | 1 | 6 |
| 400 | 0 | 2 |
| CRU frequency | 1 in 109 (95% confidence interval: 1 in 77 to 1 in 154) | |
To determine the frequency of CRUs, recipient mice were analyzed at 8 weeks after transplantation. Negative mice were defined as animals with less than 1% of donor cell contribution in recipient PB. The frequency of CRUs was calculated by applying Poisson statistics with L-calc software.