High CDX2 transcript levels correlate with poor elimination of MRD in pediatric ALL
| CDX2 expression . | Pediatric ALL, no. of patients . | ||
|---|---|---|---|
| MRD point in time 1 . | MRD point in time 2 . | ||
| Positive . | Negative . | ||
| CDX2/PBGD ratio, % 0 ≤ ratio < 4 | 8 | 3 | 5 |
| CDX2/PBGD ratio, % 4 ≤ ratio | 9 | 9 | 0 |
| CDX2 expression . | Pediatric ALL, no. of patients . | ||
|---|---|---|---|
| MRD point in time 1 . | MRD point in time 2 . | ||
| Positive . | Negative . | ||
| CDX2/PBGD ratio, % 0 ≤ ratio < 4 | 8 | 3 | 5 |
| CDX2/PBGD ratio, % 4 ≤ ratio | 9 | 9 | 0 |
Negative/low CDX2 expressers convert significantly better from positive MRD status at MRD point in time 1 to negative MRD status at MRD point in time 2, in comparison with pediatric ALL patients showing higher initial CDX2 transcripts (CDX2/PBGD ratio [%] 4 ≤ ratio). (SAS procedure FREG; Fisher exact test, P = .016).