Differential biodistribution of injected DCs within pancreatic lymph nodes
| . | PDLN (right PLN) . | GLN (left PLN) . |
|---|---|---|
| Luc+ DCs injected iv, n = 10, P = .026 | 4159 | 6421 |
| 2608 | 20 912 | |
| 1930 | 68 992 | |
| 10 734 | 42 320 | |
| 12 290 | 20 159 | |
| 3221 | 75 483 | |
| 720 | 24 200 | |
| 1056 | 1560 | |
| 3980 | 3793 | |
| 789 | 2410 | |
| Luc+ DCs injected ip, n = 5, P = .6 | 29 807 | 20 505 |
| 9414 | 209 820 | |
| 35 204 | 27 404 | |
| 72 334 | 5801 | |
| 21 093 | 33 595 |
| . | PDLN (right PLN) . | GLN (left PLN) . |
|---|---|---|
| Luc+ DCs injected iv, n = 10, P = .026 | 4159 | 6421 |
| 2608 | 20 912 | |
| 1930 | 68 992 | |
| 10 734 | 42 320 | |
| 12 290 | 20 159 | |
| 3221 | 75 483 | |
| 720 | 24 200 | |
| 1056 | 1560 | |
| 3980 | 3793 | |
| 789 | 2410 | |
| Luc+ DCs injected ip, n = 5, P = .6 | 29 807 | 20 505 |
| 9414 | 209 820 | |
| 35 204 | 27 404 | |
| 72 334 | 5801 | |
| 21 093 | 33 595 |
Luminescence measured (photons/sec per cm2) using ex vivo imaging of PDLN and GLN from NOD mice, 2 days after intravenous or intraperitoneal injection of Luc+ DCs, showing preferential homing to GLN after intravenous injection (P = .026, n = 10, paired t test), but not after intraperitoneal injection (P = .6, n = 5, paired t test). Data pooled from 2 independent experiments.
iv indicates intravenously; and ip, intraperitoneally.