Genomic alterations in CD38+ versus CD38−
| Locus . | 355 (25%) . | Sample (CD38 status %) 625 (54%) . | 931 (63%) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | |
| 1p22.1 | Loss | Loss | Neutral | ||||||
| 4q13.3-q22.1 | Loss | Loss | Neutral | Loss | Loss | Loss | |||
| 4q32.1 | Loss | Loss | Neutral | ||||||
| 5q13.1-q13.2 | Loss | Loss | Loss | ||||||
| 5q13.3-q14.1 | Loss | Loss | Loss | ||||||
| 5q14.3-q15 | Loss | Loss | Loss | ||||||
| 5q21.1-q21.3 | Loss | Loss | Loss | ||||||
| 5q21.3 | Loss | Loss | Loss | ||||||
| 8p23.3-p12 | Loss | Loss | Neutral | ||||||
| 8p11.22-p11.21 | Loss | Loss | Neutral | ||||||
| 11q22.3-q23.3 | Gain | Gain | Loss | Loss | Loss | Neutral | |||
| 11q23.3-q24.1 | Loss | Loss | Neutral | ||||||
| 17p13.3-q21.31 | Loss | Loss | Neutral | ||||||
| 17q24.2-q25.3 | Loss | Loss | Neutral | ||||||
| 18p11.32-p11.21 | Gain | Loss | Loss | Loss | Loss | Loss | |||
| 18q22.3-q23 | Gain | Neutral | Loss | ||||||
| 21q22.11-q22.3 | Loss | Gain | Gain | ||||||
| Locus . | 355 (25%) . | Sample (CD38 status %) 625 (54%) . | 931 (63%) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | 38+ vs − . | 38+ vs PMN . | 38− vs PMN . | |
| 1p22.1 | Loss | Loss | Neutral | ||||||
| 4q13.3-q22.1 | Loss | Loss | Neutral | Loss | Loss | Loss | |||
| 4q32.1 | Loss | Loss | Neutral | ||||||
| 5q13.1-q13.2 | Loss | Loss | Loss | ||||||
| 5q13.3-q14.1 | Loss | Loss | Loss | ||||||
| 5q14.3-q15 | Loss | Loss | Loss | ||||||
| 5q21.1-q21.3 | Loss | Loss | Loss | ||||||
| 5q21.3 | Loss | Loss | Loss | ||||||
| 8p23.3-p12 | Loss | Loss | Neutral | ||||||
| 8p11.22-p11.21 | Loss | Loss | Neutral | ||||||
| 11q22.3-q23.3 | Gain | Gain | Loss | Loss | Loss | Neutral | |||
| 11q23.3-q24.1 | Loss | Loss | Neutral | ||||||
| 17p13.3-q21.31 | Loss | Loss | Neutral | ||||||
| 17q24.2-q25.3 | Loss | Loss | Neutral | ||||||
| 18p11.32-p11.21 | Gain | Loss | Loss | Loss | Loss | Loss | |||
| 18q22.3-q23 | Gain | Neutral | Loss | ||||||
| 21q22.11-q22.3 | Loss | Gain | Gain | ||||||
Three CLL samples exhibit clonality with respect to CD38. All 3 samples exhibit differences between CD38+ and CD38− fractions.