Phenotypic classification of VWD
| VWD type . | Pathophysiologic mechanism . |
|---|---|
| 1 | Partial quantitative deficiency of VWF and/or FVIII |
| 2 | Qualitative defects of VWF |
| A | ↓ platelet-dependent VWF function, lack of HMWM |
| B | ↑ platelet-dependent VWF function, lack of HMWM |
| M | ↓ VWF function, normal multimers |
| N | ↓ VWF binding to FVIII, normal multimers |
| 3 | Severe/complete deficiency of VWF and moderately severe decrease of FVIII |
| VWD type . | Pathophysiologic mechanism . |
|---|---|
| 1 | Partial quantitative deficiency of VWF and/or FVIII |
| 2 | Qualitative defects of VWF |
| A | ↓ platelet-dependent VWF function, lack of HMWM |
| B | ↑ platelet-dependent VWF function, lack of HMWM |
| M | ↓ VWF function, normal multimers |
| N | ↓ VWF binding to FVIII, normal multimers |
| 3 | Severe/complete deficiency of VWF and moderately severe decrease of FVIII |