Number and frequency of wild-type and Mll5 mutant pups in litters of Mll5+/− intercrosses at the time of weaning
| No. of typed offspring . | Genotype . | P* . | ||
|---|---|---|---|---|
| +/+, no. (%) . | +/−, no. (%) . | −/−, no. (%) . | ||
| Line 87 | ||||
| Females (n = 207) | 62 (30.0) | 107 (51.7) | 38 (18.4) | .091 |
| Males (n = 213) | 67 (31.5) | 114 (53.5) | 32 (15.0) | .014 |
| Total (n = 420) | 129 (30.7) | 221 (52.6) | 70 (16.7) | .003 |
| Line 315 | ||||
| Females (n = 266) | 86 (32.3) | 145 (54.5) | 35 (13.2) | .001 |
| Males (n = 250) | 76 (30.4) | 140 (56.0) | 34 (13.6) | .006 |
| Total (n = 516) | 162 (31.4) | 285 (55.2) | 69 (13.4) | < .001 |
| No. of typed offspring . | Genotype . | P* . | ||
|---|---|---|---|---|
| +/+, no. (%) . | +/−, no. (%) . | −/−, no. (%) . | ||
| Line 87 | ||||
| Females (n = 207) | 62 (30.0) | 107 (51.7) | 38 (18.4) | .091 |
| Males (n = 213) | 67 (31.5) | 114 (53.5) | 32 (15.0) | .014 |
| Total (n = 420) | 129 (30.7) | 221 (52.6) | 70 (16.7) | .003 |
| Line 315 | ||||
| Females (n = 266) | 86 (32.3) | 145 (54.5) | 35 (13.2) | .001 |
| Males (n = 250) | 76 (30.4) | 140 (56.0) | 34 (13.6) | .006 |
| Total (n = 516) | 162 (31.4) | 285 (55.2) | 69 (13.4) | < .001 |
Cumulative data collected from 16 (line 87) and 18 (line 315) separate heterozygous × heterozygous breeding pairs. All breeders were of fifth-generation backcross C57BL/6. Time of weaning was 4 to 5 weeks after birth.
Calculation of P values was based on the χ2 test for goodness of fit to compare distribution of genotypes with the Mendelian 1:2:1 ratio.