Summary of strains used in the research
| Figure no. . | RBC donor . | Recipient . | BMT donor . | Main conclusion . |
|---|---|---|---|---|
| 2A-B | ||||
| Strain | BALB.B | B6 | BALB.B | Exposure to mHAs in leukoreduced RBC units induce BMT rejection. |
| MHC | H-2b | H-2b | H-2b | |
| mHA | BALB* | B6 | BALB* | |
| 2C-D | ||||
| Strain | BALB/c | B6 | BALB.B | The indirect presentation pathway is sufficient to induce BMT rejection. |
| MHC | H-2d* | H-2b | H-2b | |
| mHA | BALB* | B6 | BALB* | |
| 2E-G | ||||
| Strain | B6.H2d* | B6 | BALB.B | Immunization against H-2d is not responsible for mHA-mismatched BMT rejection. |
| MHC | H-2d* | H-2b | H-2b | |
| mHA | B6 | B6 | BALB* | |
| 3 | ||||
| Strain | Male B10.BR | Female B6 | Male B6 | Removal of leukocyte-associated mHAs by filtration leukoreduction is sufficient to prevent BMT rejection. |
| MHC | H-2k* | H-2b | H-2b | |
| mHA | HY* | — | HY* |
| Figure no. . | RBC donor . | Recipient . | BMT donor . | Main conclusion . |
|---|---|---|---|---|
| 2A-B | ||||
| Strain | BALB.B | B6 | BALB.B | Exposure to mHAs in leukoreduced RBC units induce BMT rejection. |
| MHC | H-2b | H-2b | H-2b | |
| mHA | BALB* | B6 | BALB* | |
| 2C-D | ||||
| Strain | BALB/c | B6 | BALB.B | The indirect presentation pathway is sufficient to induce BMT rejection. |
| MHC | H-2d* | H-2b | H-2b | |
| mHA | BALB* | B6 | BALB* | |
| 2E-G | ||||
| Strain | B6.H2d* | B6 | BALB.B | Immunization against H-2d is not responsible for mHA-mismatched BMT rejection. |
| MHC | H-2d* | H-2b | H-2b | |
| mHA | B6 | B6 | BALB* | |
| 3 | ||||
| Strain | Male B10.BR | Female B6 | Male B6 | Removal of leukocyte-associated mHAs by filtration leukoreduction is sufficient to prevent BMT rejection. |
| MHC | H-2k* | H-2b | H-2b | |
| mHA | HY* | — | HY* |
— indicates not applicable.
MHC and mHA mismatches to the recipient.