Comorbidities
| Comorbidity . | Comorbidity definition5 . | Total no. of subjects with the comorbidity in our cohort . |
|---|---|---|
| Arrhythmia | Atrial fibrillation/flutter, sick sinus syndrome, or ventricular arrhythmias | 2 |
| Cardiac | Coronary artery disease, congestive heart failure, myocardial infarction, or EF ≤ 50% | 6 |
| Heart valve disease | Except mitral valve prolapse | 4 |
| Peptic ulcer | Requiring treatment | 0 |
| Prior solid tumor | Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer | 8 |
| Psychiatric disturbance | Depression or anxiety requiring psychiatric consult or treatment | 7 |
| Obesity | Patients with a body mass index ≥ 35 kg/m2 | 3 |
| Infection | Requiring continuation of antimicrobial treatment after day 0 | 18 |
| Moderate/severe renal | Serum creatinine > 2mg/dL, on dialysis or prior renal transplantation | 2 |
| Rheumatologic disorders | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 1 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemic, but not diet alone | 3 |
| Moderate pulmonary | DLCO and/or FEV1 66%-80% or dyspnea on slight activity | 29 |
| Severe pulmonary | DLCO and/or FEV1 ≤ 65% or dyspnea at rest or requiring oxygen | 12 |
| Moderate/severe hepatic | Liver cirrhosis, bilirubin > 1.5× ULN, or AST/ALT > 2.5× ULN | 26 |
| Mild hepatic | Chronic hepatitis, bilirubin > ULN to 1.5× ULN, or AST/ALT > ULN to 2.5× ULN | 40 |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 4 |
| Inflammatory bowel disease | Crohn disease or ulcerative colitis | 2 |
| Comorbidity . | Comorbidity definition5 . | Total no. of subjects with the comorbidity in our cohort . |
|---|---|---|
| Arrhythmia | Atrial fibrillation/flutter, sick sinus syndrome, or ventricular arrhythmias | 2 |
| Cardiac | Coronary artery disease, congestive heart failure, myocardial infarction, or EF ≤ 50% | 6 |
| Heart valve disease | Except mitral valve prolapse | 4 |
| Peptic ulcer | Requiring treatment | 0 |
| Prior solid tumor | Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer | 8 |
| Psychiatric disturbance | Depression or anxiety requiring psychiatric consult or treatment | 7 |
| Obesity | Patients with a body mass index ≥ 35 kg/m2 | 3 |
| Infection | Requiring continuation of antimicrobial treatment after day 0 | 18 |
| Moderate/severe renal | Serum creatinine > 2mg/dL, on dialysis or prior renal transplantation | 2 |
| Rheumatologic disorders | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 1 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemic, but not diet alone | 3 |
| Moderate pulmonary | DLCO and/or FEV1 66%-80% or dyspnea on slight activity | 29 |
| Severe pulmonary | DLCO and/or FEV1 ≤ 65% or dyspnea at rest or requiring oxygen | 12 |
| Moderate/severe hepatic | Liver cirrhosis, bilirubin > 1.5× ULN, or AST/ALT > 2.5× ULN | 26 |
| Mild hepatic | Chronic hepatitis, bilirubin > ULN to 1.5× ULN, or AST/ALT > ULN to 2.5× ULN | 40 |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 4 |
| Inflammatory bowel disease | Crohn disease or ulcerative colitis | 2 |
EF indicates ejection fraction; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; CTD, connective tissue disease; DLCO, diffusing lung capacity for carbon monoxide; FEV1, forced expiratory volume in 1 second; ULN, upper limit of normal; AST, aspartate aminotransferase; and ALT, alanine aminotransferase.