Comparison of genetic parameters between paired samples of diagnosis, first, and second relapse
| . | Diagnosis n = 84 . | 1. Relapse n = 84 . | 2. Relapse n = 9 . |
|---|---|---|---|
| NPM1 level | Median: 546.4 | Median: 344.4 | Median: 359.5 |
| Range: 20.5-8842.9 | Range: 5.2-4532.9 | Range: 23.3-3040.6 | |
| FLT3-LM | + (n = 31) | + (n = 5) | |
| (n = 80) | + (n = 34) | ||
| − (n = 3) | |||
| − (n = 32) | − (n = 3) | ||
| − (n = 46) | |||
| + (n = 14) | |||
| Karyotype | NK (n = 43) | NK (n = 2) | |
| (n = 61) | NK (n = 49) | ||
| AK (n = 6) | AK (n = 2) | ||
| AK (n = 2) | AK (n = 2) | ||
| AK (n = 2) | AK + ACA (n = 2) | ||
| AK (n = 4) | Diff. AK (n = 4) | Diff. AK (n = 1) | |
| AK (n = 4) | NK (n = 4) |
| . | Diagnosis n = 84 . | 1. Relapse n = 84 . | 2. Relapse n = 9 . |
|---|---|---|---|
| NPM1 level | Median: 546.4 | Median: 344.4 | Median: 359.5 |
| Range: 20.5-8842.9 | Range: 5.2-4532.9 | Range: 23.3-3040.6 | |
| FLT3-LM | + (n = 31) | + (n = 5) | |
| (n = 80) | + (n = 34) | ||
| − (n = 3) | |||
| − (n = 32) | − (n = 3) | ||
| − (n = 46) | |||
| + (n = 14) | |||
| Karyotype | NK (n = 43) | NK (n = 2) | |
| (n = 61) | NK (n = 49) | ||
| AK (n = 6) | AK (n = 2) | ||
| AK (n = 2) | AK (n = 2) | ||
| AK (n = 2) | AK + ACA (n = 2) | ||
| AK (n = 4) | Diff. AK (n = 4) | Diff. AK (n = 1) | |
| AK (n = 4) | NK (n = 4) |
ACA indicates additional chromosomal aberrations; AK, aberrant karyotype; Diff, different; and NK, normal karyotype.