Table 3 Responses by mutation types and... | American Society of Hematology

Table 3

Responses by mutation types and disease phase

Phase/mutation status before second TKI	N	Response, %
Phase/mutation status before second TKI	N	CHR	MCyR	CCyR
CP
None	29	96	68	54
Mutated	30	77	58	52
IC₅₀ low*	15	—	87	73
IC₅₀ intermediate*	8	—	25	25
P†			.003	.026
AP
None	30	70	30	20
Mutated	41	68	34	31
IC₅₀ low	21	—	38	38
IC₅₀ intermediate	10	—	10	10
P†			.01	.01
BP
None	24	37	25	21
Mutated	15	27	20	13
IC₅₀ low	6	—	33	17
IC₅₀ intermediate	7	—	14	14
P†			.42	.9

Phase/mutation status before second TKI	N	Response, %
Phase/mutation status before second TKI	N	CHR	MCyR	CCyR
CP
None	29	96	68	54
Mutated	30	77	58	52
IC₅₀ low*	15	—	87	73
IC₅₀ intermediate*	8	—	25	25
P†			.003	.026
AP
None	30	70	30	20
Mutated	41	68	34	31
IC₅₀ low	21	—	38	38
IC₅₀ intermediate	10	—	10	10
P†			.01	.01
BP
None	24	37	25	21
Mutated	15	27	20	13
IC₅₀ low	6	—	33	17
IC₅₀ intermediate	7	—	14	14
P†			.42	.9

— indicates not reported.

In vitro IC₅₀ for a given TKI for a given mutation.

Comparing low versus intermediate mutation classes.