Overview of the pathologic conditions, other than lymphomas, causing splenomegaly
| Disease type . | Representative examples . |
|---|---|
| Infective | Brucellosis, EBV and CMV infections, Leishmaniasis, viral hepatitis |
| Myeloproliferative neoplasms | PMF, CML, PV, CMML |
| Hemolytic anemia | Thalassemia, sickle cell anemia, hereditary spherocytosis, autoimmune hemolytic anemia |
| Hepatic diseases and veno-occlusive disorders of hepatic veins and portal system | Cirrhosis, hepatic/portal/splenic vein thrombosis |
| Autoimmune and inflammatory diseases | SLE, Felty syndrome, sarcoidosis, inflammatory pseudotumor of the spleen |
| Tumors | Littoral cell angioma, hemangioma, lymphangioma, spindle-cell sarcomas, metastases |
| Protein misfolding diseases and thesaurismoses | Amyloidosis, Gaucher disease, Erdheim-Chester disease |
| Other conditions | Cysts, infarction |
| Disease type . | Representative examples . |
|---|---|
| Infective | Brucellosis, EBV and CMV infections, Leishmaniasis, viral hepatitis |
| Myeloproliferative neoplasms | PMF, CML, PV, CMML |
| Hemolytic anemia | Thalassemia, sickle cell anemia, hereditary spherocytosis, autoimmune hemolytic anemia |
| Hepatic diseases and veno-occlusive disorders of hepatic veins and portal system | Cirrhosis, hepatic/portal/splenic vein thrombosis |
| Autoimmune and inflammatory diseases | SLE, Felty syndrome, sarcoidosis, inflammatory pseudotumor of the spleen |
| Tumors | Littoral cell angioma, hemangioma, lymphangioma, spindle-cell sarcomas, metastases |
| Protein misfolding diseases and thesaurismoses | Amyloidosis, Gaucher disease, Erdheim-Chester disease |
| Other conditions | Cysts, infarction |
EBV indicates Epstein-Barr virus; CMV, cytomegalovirus; PMF, primary myelofibrosis; CML, chronic myelogenous leukemia; PV, polycythemia vera; CMML, chronic myelomonocytic leukemia; and SLE, systemic lupus erythematosus.