SL entities
| B-cell . | Flow cytometry immunophenotype . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| κλ > 4 or < 0.5 . | sIg; cIg . | CD20 . | CD5 . | CD10 . | CD23 . | FMC7 . | CD11c . | CD25 . | CD103 . | CD38 . | Cyclin-D1 . | |
| SMZL | + | +;−/+ | + | −/+ | − | −/+ | + | +/− | −/+ | − | −/+ | − |
| SLL-u | ||||||||||||
| SDRPBCL | + | +/−;− | + | −/+ | − | − | + | + | − | −/+ | − | − |
| HCL-v | + | +;− | + | − | − | − | + | + | − | + | NA | NA |
| HCL | + | +;− | + | − | − | − | + | + | + | + | NA | +/− |
| LPL | + | +/−;+ | + | −/+ | −/+ | −/+ | + | − | + | − | + | − |
| B-PLL | + | + | + | −/+ | − | −/+ | + | + | − | − | +/− | − |
| MCL* | + | +;− | + | + | − | − | + | − | −/+ | − | −/+ | + |
| FL* | + | +;− | + | − | +/− | −/+ | + | − | − | − | NA | − |
| DLBCL* | +/− | +/−; −/+ | + | − | +/− | − | + | NA | − | NA | − | − |
| MTLBL* | +/− | +/−; −/+ | + | − | − | − | NA | NA | NA | NA | − | − |
| T-cell | TCRαβ | TCRγδ | CD2 | CD3 | CD5 | CD7 | CD4 | CD8 | CD25 | CD16 | CD56 | CD57 |
| T-LGL | + | − | + | + | −/+ | −/+ | − | + | − | + | − | + |
| HSTL | − | + | + | + | − | + | − | −/+ | − | − | +/− | − |
| B-cell . | Flow cytometry immunophenotype . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| κλ > 4 or < 0.5 . | sIg; cIg . | CD20 . | CD5 . | CD10 . | CD23 . | FMC7 . | CD11c . | CD25 . | CD103 . | CD38 . | Cyclin-D1 . | |
| SMZL | + | +;−/+ | + | −/+ | − | −/+ | + | +/− | −/+ | − | −/+ | − |
| SLL-u | ||||||||||||
| SDRPBCL | + | +/−;− | + | −/+ | − | − | + | + | − | −/+ | − | − |
| HCL-v | + | +;− | + | − | − | − | + | + | − | + | NA | NA |
| HCL | + | +;− | + | − | − | − | + | + | + | + | NA | +/− |
| LPL | + | +/−;+ | + | −/+ | −/+ | −/+ | + | − | + | − | + | − |
| B-PLL | + | + | + | −/+ | − | −/+ | + | + | − | − | +/− | − |
| MCL* | + | +;− | + | + | − | − | + | − | −/+ | − | −/+ | + |
| FL* | + | +;− | + | − | +/− | −/+ | + | − | − | − | NA | − |
| DLBCL* | +/− | +/−; −/+ | + | − | +/− | − | + | NA | − | NA | − | − |
| MTLBL* | +/− | +/−; −/+ | + | − | − | − | NA | NA | NA | NA | − | − |
| T-cell | TCRαβ | TCRγδ | CD2 | CD3 | CD5 | CD7 | CD4 | CD8 | CD25 | CD16 | CD56 | CD57 |
| T-LGL | + | − | + | + | −/+ | −/+ | − | + | − | + | − | + |
| HSTL | − | + | + | + | − | + | − | −/+ | − | − | +/− | − |
κλ indicates κ-to-λ light chain ratio; sIg, surface immunoglobulin; cIg cytoplasmatic immunoglobulin; CD, cluster of differentiation; NA, not applicable; TCR, T-cell receptor; SDRPBCL, splenic diffuse red pulp B-cell lymphoma; HCL-v, hairy cell leukemia variant; and MTLBL, micronodular T-cell rich histiocyte-rich diffuse large B-cell lymphoma.
+ indicates usually positive (ie, ∼ 90% of cases or more are positive); −, usually negative; and +/− and −/+ may be positive or negative (the first sign indicating the more frequent condition).
Primary splenic form.