Subject characteristics for TLC patients: patients screened by Doppler echocardiography with a reported TRV versus patients screened without a reported TRV
| . | Patients with TRV reported, n = 148 . | Patients with no TRV reported, n = 177 . | Total, n = 325 . | P* . |
|---|---|---|---|---|
| Age at enrollment, mean (SD) | 25.9 (12.1) | 22.6 (11.6) | 24.1 (11.9) | .01 |
| Sex, n (%) | ||||
| Male | 78 (52.7) | 79 (44.6) | 157 (48.3) | .15 |
| Female | 70 (47.3) | 98 (55.4) | 168 (51.7) | |
| Race, n (%)† | ||||
| White | 75 (51.4) | 80 (45.7) | 155 (48.3) | .61 |
| Black | 2 (1.4) | 4 (2.3) | 6 (1.9) | |
| Asian | 64 (43.8) | 87 (49.7) | 151 (47.0) | |
| Other | 5 (3.4) | 4 (2.3) | 9 (2.8) | |
| Diagnosis, n (%)‡ | ||||
| β-thalassemia, transfused ≥ 8 times/previous 12 mo | 108 (73.0) | 140 (79.1) | 248 (76.3) | .07 |
| β-thalassemia, with a history of transfusion but < 8 times/previous 12 mo | 9 (6.1) | 12 (6.8) | 21 (6.5) | |
| β-thalassemia, never transfused | 1 (0.7) | 4 (2.3) | 5 (1.5) | |
| HbH disease | 1 (0.7) | 0 (0.0) | 1 (0.3) | |
| HbH Constant Spring disease | 3 (2.0) | 3 (1.7) | 6 (1.8) | |
| E-β-thalassemia, transfused ≥ 8 times/previous 12 mo | 18 (12.1) | 10 (5.7) | 28 (8.6) | |
| E-β-thalassemia, with a history of transfusion but < 8 times/previous 12 mo | 5 (3.4) | 3 (1.7) | 8 (2.5) | |
| E-β-thalassemia, never transfused | 1 (0.7) | 0 (0.0) | 1 (0.3) | |
| Homozygous α-thalassemia | 0 (0.0) | 5 (2.8) | 5 (1.5) | |
| Other | 2 (1.4) | 0 (0.0) | 2 (0.6) |
| . | Patients with TRV reported, n = 148 . | Patients with no TRV reported, n = 177 . | Total, n = 325 . | P* . |
|---|---|---|---|---|
| Age at enrollment, mean (SD) | 25.9 (12.1) | 22.6 (11.6) | 24.1 (11.9) | .01 |
| Sex, n (%) | ||||
| Male | 78 (52.7) | 79 (44.6) | 157 (48.3) | .15 |
| Female | 70 (47.3) | 98 (55.4) | 168 (51.7) | |
| Race, n (%)† | ||||
| White | 75 (51.4) | 80 (45.7) | 155 (48.3) | .61 |
| Black | 2 (1.4) | 4 (2.3) | 6 (1.9) | |
| Asian | 64 (43.8) | 87 (49.7) | 151 (47.0) | |
| Other | 5 (3.4) | 4 (2.3) | 9 (2.8) | |
| Diagnosis, n (%)‡ | ||||
| β-thalassemia, transfused ≥ 8 times/previous 12 mo | 108 (73.0) | 140 (79.1) | 248 (76.3) | .07 |
| β-thalassemia, with a history of transfusion but < 8 times/previous 12 mo | 9 (6.1) | 12 (6.8) | 21 (6.5) | |
| β-thalassemia, never transfused | 1 (0.7) | 4 (2.3) | 5 (1.5) | |
| HbH disease | 1 (0.7) | 0 (0.0) | 1 (0.3) | |
| HbH Constant Spring disease | 3 (2.0) | 3 (1.7) | 6 (1.8) | |
| E-β-thalassemia, transfused ≥ 8 times/previous 12 mo | 18 (12.1) | 10 (5.7) | 28 (8.6) | |
| E-β-thalassemia, with a history of transfusion but < 8 times/previous 12 mo | 5 (3.4) | 3 (1.7) | 8 (2.5) | |
| E-β-thalassemia, never transfused | 1 (0.7) | 0 (0.0) | 1 (0.3) | |
| Homozygous α-thalassemia | 0 (0.0) | 5 (2.8) | 5 (1.5) | |
| Other | 2 (1.4) | 0 (0.0) | 2 (0.6) |