Percent of patients with at least one grade 3 or 4 side effect classified by CTC criteria and NCI criteria according to randomization group
| . | Chlorambucil (n = 96) . | Fludarabine (n = 87) . | P . |
|---|---|---|---|
| CTC grade 3 and 4 | |||
| Myelotoxicity in general | 23 | 42 | .005 |
| Leukocytopenia | 3 | 28 | < .001 |
| Neutropenia | 12 | 12 | 1.0 |
| Anemia | 27 | 15 | .05 |
| AIHA | 2 | 8 | .08 |
| Thrombocytopenia | 20 | 15 | .4 |
| Infection | 4 | 8 | .3 |
| NCI grade 3 and 4 | |||
| Neutropenia | 40 | 40 | 1.0 |
| Anemia | 6 | 1 | .08 |
| Thrombocytopenia | 25 | 29 | .5 |
| . | Chlorambucil (n = 96) . | Fludarabine (n = 87) . | P . |
|---|---|---|---|
| CTC grade 3 and 4 | |||
| Myelotoxicity in general | 23 | 42 | .005 |
| Leukocytopenia | 3 | 28 | < .001 |
| Neutropenia | 12 | 12 | 1.0 |
| Anemia | 27 | 15 | .05 |
| AIHA | 2 | 8 | .08 |
| Thrombocytopenia | 20 | 15 | .4 |
| Infection | 4 | 8 | .3 |
| NCI grade 3 and 4 | |||
| Neutropenia | 40 | 40 | 1.0 |
| Anemia | 6 | 1 | .08 |
| Thrombocytopenia | 25 | 29 | .5 |
AIHA indicates autoimmune hemolytic anemia.