Table 2 Cystine content in different... | American Society of Hematology

Table 2

Cystine content in different tissues of treated and control mice at 2 and 4 months after transplantation

Tissue	2 months (n = 3 animals per group)				4 months (n = 12 animals per group)
Tissue	Wild-type controls	Ctns^−/− BMCs	WT BMCs	WT MSCs	Wild-type controls	Ctns^−/− BMCs	WT BMCs	WT MSCs
Brain	0.02 ± 0.00	0.70 ± 0.15	0.61 ± 0.29	0.75 ± 0.28	0.02 ± 0.00	1.38 ± 0.45	0.59 ± 0.32*	0.62 ± 0.39*
Eye	0.07 ± 0.20	20 ± 11	18 ± 11	27 ± 4	0.1 ± 0.02	45 ± 12	13 ± 8*	36 ± 9
Heart	0.17 ± 0.10	25 ± 7	23 ± 16	10 ± 1*	0.08 ± 0.10	61 ± 15	11 ± 8*	25 ± 9*
Kidney	0.18 ± 0.05	76 ± 16	135 ± 12	45 ± 24	0.25 ± 0.06	116 ± 63	35 ± 34*	59 ± 34*
Liver	0.02 ± 0.01	57 ± 3	6 ± 0.2*	62 ± 23	0.02 ± 0.02	62 ± 19	3 ± 1*	51 ± 15
Muscle	0.23 ± 0.13	17 ± 7	15 ± 2	10 ± 0.7	0.07 ± 0.20	30 ± 11	10 ± 6*	22 ± 4
Spleen	0.06 ± 0.04	91 ± 39	38 ± 5*	124 ± 35	0.12 ± 0.03	160 ± 50	21 ± 19*	95 ± 17*

Tissue	2 months (n = 3 animals per group)				4 months (n = 12 animals per group)
Tissue	Wild-type controls	Ctns^−/− BMCs	WT BMCs	WT MSCs	Wild-type controls	Ctns^−/− BMCs	WT BMCs	WT MSCs
Brain	0.02 ± 0.00	0.70 ± 0.15	0.61 ± 0.29	0.75 ± 0.28	0.02 ± 0.00	1.38 ± 0.45	0.59 ± 0.32*	0.62 ± 0.39*
Eye	0.07 ± 0.20	20 ± 11	18 ± 11	27 ± 4	0.1 ± 0.02	45 ± 12	13 ± 8*	36 ± 9
Heart	0.17 ± 0.10	25 ± 7	23 ± 16	10 ± 1*	0.08 ± 0.10	61 ± 15	11 ± 8*	25 ± 9*
Kidney	0.18 ± 0.05	76 ± 16	135 ± 12	45 ± 24	0.25 ± 0.06	116 ± 63	35 ± 34*	59 ± 34*
Liver	0.02 ± 0.01	57 ± 3	6 ± 0.2*	62 ± 23	0.02 ± 0.02	62 ± 19	3 ± 1*	51 ± 15
Muscle	0.23 ± 0.13	17 ± 7	15 ± 2	10 ± 0.7	0.07 ± 0.20	30 ± 11	10 ± 6*	22 ± 4
Spleen	0.06 ± 0.04	91 ± 39	38 ± 5*	124 ± 35	0.12 ± 0.03	160 ± 50	21 ± 19*	95 ± 17*

Cystine content is stated in nmol half-cystine/mg protein.

P < .05 versus mice treated with Ctns^−/− BMCs.