Survival after initial therapy in newly diagnosed myeloma patients according to IMWG response, serum M-spike response, initial PCLI, and PCLI response
| Stratification . | All patients, median OS . | P . | PCLI response . | No PCLI response . | P . |
|---|---|---|---|---|---|
| PCLI response, mo | .02* | – | |||
| ≥ 60% reduction (n = 94) | 54 | – | – | – | |
| < 60% reduction (n = 82) | 29 | – | – | – | |
| Initial PCLI, median OS | .001* | ||||
| < 1% (low, n = 60) | 56 | 66 mo | 49 mo | .56 | |
| ≥ 1 < 3% (intermediate, n = 94) | 49 | 64 mo | 24 mo | .002* | |
| ≥ 3% (high, n = 22) | 17 | 28 mo | 7 mo | .003* | |
| Serum M-spike response, mo | .004* | ||||
| ≥ 50% reduction (n = 92) | 55 | 62 mo | 47 mo | .32 | |
| < 50% reduction (n = 54) | 29 | 49 mo | 21 mo | .03* | |
| IMWG response, mo or % | < .001* | ||||
| CR (n = 4) | † | † | 50% | 50% | 1.0 |
| VGPR (n = 12) | 64 | – | 75% | 25% | .08 |
| PR (n = 88) | 55 | – | 65% | 35% | .004* |
| SD/PD (n = 72) | 28 | – | 37.5% | 62.5% | .003* |
| Stratification . | All patients, median OS . | P . | PCLI response . | No PCLI response . | P . |
|---|---|---|---|---|---|
| PCLI response, mo | .02* | – | |||
| ≥ 60% reduction (n = 94) | 54 | – | – | – | |
| < 60% reduction (n = 82) | 29 | – | – | – | |
| Initial PCLI, median OS | .001* | ||||
| < 1% (low, n = 60) | 56 | 66 mo | 49 mo | .56 | |
| ≥ 1 < 3% (intermediate, n = 94) | 49 | 64 mo | 24 mo | .002* | |
| ≥ 3% (high, n = 22) | 17 | 28 mo | 7 mo | .003* | |
| Serum M-spike response, mo | .004* | ||||
| ≥ 50% reduction (n = 92) | 55 | 62 mo | 47 mo | .32 | |
| < 50% reduction (n = 54) | 29 | 49 mo | 21 mo | .03* | |
| IMWG response, mo or % | < .001* | ||||
| CR (n = 4) | † | † | 50% | 50% | 1.0 |
| VGPR (n = 12) | 64 | – | 75% | 25% | .08 |
| PR (n = 88) | 55 | – | 65% | 35% | .004* |
| SD/PD (n = 72) | 28 | – | 37.5% | 62.5% | .003* |
IMWG response was determined by standard IMWG response criteria. Serum M spike was defined as 50% of more reduction in the baseline M spike after therapy. Baseline PCLI values were stratified by low (< 1%), intermediate (≥ 1%), and high (≥ 3%) groups.
Cumulative percentages may not equal 100% because of rounding.
CR indicates complete response; IMWG, International Myeloma Working Group; OS, overall survival; PCLI, plasma cell labeling index; PR, partial response; and VGPR, very good partial response.
Statistically significant.
Complete response median OS was not reached.