KEGG pathways with the most genes up-regulated and down-regulated in CD34+ cells mobilized by plerixafor plus G-CSF compared with those mobilized by plerixafor alone and G-CSF alone
| Pathways with genes up-regulated by plerixafor plus G-CSF . | Pathways with genes down-regulated by plerixafor plus G-CSF . | ||
|---|---|---|---|
| Pathway . | No. of up-regulated genes in pathway . | Pathway . | No. of down-regulated genes in pathway . |
| Cytokine-cytokine receptor interaction | 68 | MAPK signaling pathway | 51 |
| MAPK signaling pathway | 63 | Focal adhesion | 46 |
| Natural killer cell–mediated cytotoxicity | 41 | Oxidative phosphorylation | 40 |
| Jak-STAT signaling pathway | 39 | Calcium signaling pathway | 37 |
| Focal adhesion | 33 | Ribosome | 36 |
| Leukocyte transendothelial migration | 33 | Cytokine-cytokine receptor interaction | 33 |
| Regulation of actin cytoskeleton | 32 | Wnt signaling pathway | 33 |
| Insulin signaling pathway | 29 | Tight junction | 31 |
| Cell cycle | 28 | Jak-STAT signaling pathway | 29 |
| Gap junction | 28 | Cell adhesion molecules | 28 |
| Calcium signaling pathway | 25 | Natural killer cell–mediated cytotoxicity | 28 |
| Fc epsilon RI signaling pathway | 25 | Insulin signaling pathway | 27 |
| Oxidative phosphorylation | 25 | Axon guidance | 26 |
| Ubiquitin mediated proteolysis | 25 | ErbB signaling pathway | 25 |
| T-cell receptor signaling pathway | 24 | Small cell lung cancer | 25 |
| B-cell receptor signaling pathway | 22 | Antigen processing and presentation | 23 |
| Cell adhesion molecules | 22 | Leukocyte transendothelial migration | 23 |
| Toll-like receptor signaling pathway | 22 | Gap junction | 22 |
| Wnt signaling pathway | 22 | Hematopoietic cell lineage | 22 |
| GnRH signaling pathway | 21 | Long-term depression | 22 |
| Melanogenesis | 21 | Regulation of actin cytoskeleton | 22 |
| Tight junction | 21 | VEGF signaling pathway | 22 |
| Apoptosis | 20 | Colorectal cancer | 21 |
| Hematopoietic cell lineage | 20 | T-cell receptor signaling pathway | 21 |
| Pathogenic Escherichia coli infection—EHEC | 20 | Ubiquitin mediated proteolysis | 21 |
| Pathways with genes up-regulated by plerixafor plus G-CSF . | Pathways with genes down-regulated by plerixafor plus G-CSF . | ||
|---|---|---|---|
| Pathway . | No. of up-regulated genes in pathway . | Pathway . | No. of down-regulated genes in pathway . |
| Cytokine-cytokine receptor interaction | 68 | MAPK signaling pathway | 51 |
| MAPK signaling pathway | 63 | Focal adhesion | 46 |
| Natural killer cell–mediated cytotoxicity | 41 | Oxidative phosphorylation | 40 |
| Jak-STAT signaling pathway | 39 | Calcium signaling pathway | 37 |
| Focal adhesion | 33 | Ribosome | 36 |
| Leukocyte transendothelial migration | 33 | Cytokine-cytokine receptor interaction | 33 |
| Regulation of actin cytoskeleton | 32 | Wnt signaling pathway | 33 |
| Insulin signaling pathway | 29 | Tight junction | 31 |
| Cell cycle | 28 | Jak-STAT signaling pathway | 29 |
| Gap junction | 28 | Cell adhesion molecules | 28 |
| Calcium signaling pathway | 25 | Natural killer cell–mediated cytotoxicity | 28 |
| Fc epsilon RI signaling pathway | 25 | Insulin signaling pathway | 27 |
| Oxidative phosphorylation | 25 | Axon guidance | 26 |
| Ubiquitin mediated proteolysis | 25 | ErbB signaling pathway | 25 |
| T-cell receptor signaling pathway | 24 | Small cell lung cancer | 25 |
| B-cell receptor signaling pathway | 22 | Antigen processing and presentation | 23 |
| Cell adhesion molecules | 22 | Leukocyte transendothelial migration | 23 |
| Toll-like receptor signaling pathway | 22 | Gap junction | 22 |
| Wnt signaling pathway | 22 | Hematopoietic cell lineage | 22 |
| GnRH signaling pathway | 21 | Long-term depression | 22 |
| Melanogenesis | 21 | Regulation of actin cytoskeleton | 22 |
| Tight junction | 21 | VEGF signaling pathway | 22 |
| Apoptosis | 20 | Colorectal cancer | 21 |
| Hematopoietic cell lineage | 20 | T-cell receptor signaling pathway | 21 |
| Pathogenic Escherichia coli infection—EHEC | 20 | Ubiquitin mediated proteolysis | 21 |