Table 2

Surface plasmon resonance analyses of FXII(a) binding to fibrin(ogen)

kd (off-rate, s−1)ka (on-rate, M−1s−1)Kd (dissociation constant, M)
FXII to fibrinogen 2.9 × 10−3 9.8 × 105 3.0 × 10−9 
FXII to fibrin 2.9 × 10−3 11.8 × 105 2.5 × 10−9 
α-FXIIa to fibrinogen 1.8 × 10−3 4.3 × 105 4.1 × 10−9 
α-FXIIa to fibrin 1.8 × 10−3 3.9 × 105 4.6 × 10−9 
β-FXIIa to fibrinogen 8.2 × 10−4 8.7 × 103 9.4 × 10−8 
β-FXIIa to fibrin 8.7 × 10−4 9.2 × 103 9.4 × 10−8 
kd (off-rate, s−1)ka (on-rate, M−1s−1)Kd (dissociation constant, M)
FXII to fibrinogen 2.9 × 10−3 9.8 × 105 3.0 × 10−9 
FXII to fibrin 2.9 × 10−3 11.8 × 105 2.5 × 10−9 
α-FXIIa to fibrinogen 1.8 × 10−3 4.3 × 105 4.1 × 10−9 
α-FXIIa to fibrin 1.8 × 10−3 3.9 × 105 4.6 × 10−9 
β-FXIIa to fibrinogen 8.2 × 10−4 8.7 × 103 9.4 × 10−8 
β-FXIIa to fibrin 8.7 × 10−4 9.2 × 103 9.4 × 10−8 
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