Univariate and multivariate Cox regression analyses of the risk of death of mutated (n = 21) and unmutated (n = 67) groups of patients
| Statistical analysis . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| TET2 status | ||||
| Mutated | 1 | 1 | ||
| Unmutated | 4.1 (1.4-12.0) | .010 | 5.2 (1.6-16.3) | .005 |
| Age/10 y | 1.8 (1.3-2.6) | .002 | 1.7 (1.1-2.6) | .020 |
| Number of cytopenias | ||||
| 1 | 1 | |||
| 2 or 3 | 4.3 (2.0-9.3) | < .001 | ||
| Percentage bone marrow blasts | 1.1 (1.0-1.1) | .002 | ||
| IPSS-based karyotype | ||||
| Favorable | 1 | |||
| Intermediate | 2.1 (0.9-4.8) | .078 | ||
| Unfavorable | 2.7 (1.1-6.8) | .030 | ||
| IPSS risk groups | ||||
| Low/Int-1 | 1 | 1 | ||
| Int-2/High | 5.0 (2.3-10.7) | < .001 | 9.2 (3.7-22.9) | < .001 |
| Transfusions | 2.2 (1.1-4.4) | .030 | 2.6 (1.2-5.8) | .021 |
| Statistical analysis . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| TET2 status | ||||
| Mutated | 1 | 1 | ||
| Unmutated | 4.1 (1.4-12.0) | .010 | 5.2 (1.6-16.3) | .005 |
| Age/10 y | 1.8 (1.3-2.6) | .002 | 1.7 (1.1-2.6) | .020 |
| Number of cytopenias | ||||
| 1 | 1 | |||
| 2 or 3 | 4.3 (2.0-9.3) | < .001 | ||
| Percentage bone marrow blasts | 1.1 (1.0-1.1) | .002 | ||
| IPSS-based karyotype | ||||
| Favorable | 1 | |||
| Intermediate | 2.1 (0.9-4.8) | .078 | ||
| Unfavorable | 2.7 (1.1-6.8) | .030 | ||
| IPSS risk groups | ||||
| Low/Int-1 | 1 | 1 | ||
| Int-2/High | 5.0 (2.3-10.7) | < .001 | 9.2 (3.7-22.9) | < .001 |
| Transfusions | 2.2 (1.1-4.4) | .030 | 2.6 (1.2-5.8) | .021 |
Age is indicated as 10-year increments.
CI indicates confidence interval; and HR, hazard ratio.