Genes with deregulated expression induced by the nearby RIS
| Clone . | Gene . | Description . | Vector orientation . | Insertion type . | Distance from TSS, kb . | Relative expression . | Fold change . |
|---|---|---|---|---|---|---|---|
| X24 | ACSL4 | Long-chain acyl-CoA synthetase 4 | Antisense | Intergenic | −0.45 | 4.5 | 3.8 |
| X22 | MADD | MAP-kinase activating death domain protein | Sense | Intergenic | −53.8 | 5.3 | 2.8 |
| X12 | IQGAP1 | Ras GTPase-activating-like protein | Antisense | Intergenic | 213.1 | 2.4 | 3.9 |
| Y7 | STAM | Signal transducing adapter molecule 1 | Antisense | Intergenic | 99.9 | 3.7 | 4.5 |
| Y20/Y26 | LOC57228 | Unknown | Antisense | Intergenic | −54.4 | 13.9/14.6 | NA |
| Y3 | C14orf159 | Mitochondrial precursor | Antisense | Intergenic | −0.68 | 10.4 | −4.7 |
| Y16 | RUNDC2A | RUN domain-containing protein 2A | Antisense | Intragenic | 34.4 | 9.4 | −5.2 |
| Clone . | Gene . | Description . | Vector orientation . | Insertion type . | Distance from TSS, kb . | Relative expression . | Fold change . |
|---|---|---|---|---|---|---|---|
| X24 | ACSL4 | Long-chain acyl-CoA synthetase 4 | Antisense | Intergenic | −0.45 | 4.5 | 3.8 |
| X22 | MADD | MAP-kinase activating death domain protein | Sense | Intergenic | −53.8 | 5.3 | 2.8 |
| X12 | IQGAP1 | Ras GTPase-activating-like protein | Antisense | Intergenic | 213.1 | 2.4 | 3.9 |
| Y7 | STAM | Signal transducing adapter molecule 1 | Antisense | Intergenic | 99.9 | 3.7 | 4.5 |
| Y20/Y26 | LOC57228 | Unknown | Antisense | Intergenic | −54.4 | 13.9/14.6 | NA |
| Y3 | C14orf159 | Mitochondrial precursor | Antisense | Intergenic | −0.68 | 10.4 | −4.7 |
| Y16 | RUNDC2A | RUN domain-containing protein 2A | Antisense | Intragenic | 34.4 | 9.4 | −5.2 |
List of genes displaying altered mRNA level in the ex vivo isolated T-cell clone(s) harboring RIS. T-cell clones retrieved from patient 2 are indicated with X; clones from patient 3 with Y. Vector orientation is relative to targeted gene transcription. Relative gene expression level is indicated as normalized for the housekeeping gene GAPDH in each hit clone, and as fold change relative to the calibrator, as described in “Gene expression analysis.”
NA indicates not applicable.