Multivariate analysis of the prognostic effect of OPN and other prognostic variables on overall survival
| Prognostic marker . | Level . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| OPN | High | 1.79 | 0.94-3.39 | .08 |
| Age | Continuous | 1.02 | 0.99-1.05 | .06 |
| WCC | Continuous | 1.006 | 1.001-1.012 | .02 |
| Cytogenetics | .03* | |||
| High | 3.71 | 0.91-15.08 | .07 | |
| Intermediate | 1.26 | 0.37-4.32 | .7 | |
| Low | 1.0 | — | — |
| Prognostic marker . | Level . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|---|
| OPN | High | 1.79 | 0.94-3.39 | .08 |
| Age | Continuous | 1.02 | 0.99-1.05 | .06 |
| WCC | Continuous | 1.006 | 1.001-1.012 | .02 |
| Cytogenetics | .03* | |||
| High | 3.71 | 0.91-15.08 | .07 | |
| Intermediate | 1.26 | 0.37-4.32 | .7 | |
| Low | 1.0 | — | — |
The effect of OPN expression on overall survival for 52 patients with AML treated with chemotherapy in our institution was examined in a multivariate Cox proportional hazards model that included all variables that were deemed influential in survival: OPN, age, white cell count (WCC) at diagnosis, and cytogenetic risk group. The assumptions for proportional hazards was not violated.
— indicates not applicable.
Global P value for cytogenetics.