Cardiac characteristics for control and KO mice evaluated using echocardiography
| Parameter . | 3 mo . | 6 mo . | 9 mo . | |||
|---|---|---|---|---|---|---|
| Control (n = 6) . | KO (n = 6) . | Control (n = 6) . | KO (n = 6) . | Control (n = 6) . | KO (n = 6) . | |
| Heart rate, bpm | 462 ± 40 | 489 ± 65 | 483 ± 54 | 504 ± 70 | 530 ± 27 | 505 ± 39 |
| Right ventricle characteristics | ||||||
| Thickness, mm | 0.23 ± 0.03 | 0.23 ± 0.02 | 0.22 ± 0.04 | 0.25 ± 0.07 | 0.28 ± 0.02 | 0.32 ± 0.03* |
| Diameter, mm | 1.74 ± 0.27 | 1.85 ± 0.1 | 1.46 ± 0.09 | 1.79 ± 0.1* | 1.73 ± 0.05 | 1.90 ± 0.08* |
| Left ventricle characteristics | ||||||
| Thickness IVS, mm | 0.63 ± 0.06 | 0.65 ± 0.06 | 0.65 ± 0.06 | 0.7 ± 0.12 | 0.65 ± 0.12 | 0.80 ± 0.07 |
| Thickness LVPW, mm | 0.74 ± 0.05 | 0.72 ± 0.07 | 0.73 ± 0.06 | 0.69 ± 0.13 | 0.86 ± 0.10 | 0.84 ± 0.14 |
| LVIDd, mm | 3.95 ± 0.2 | 4.07 ± 0.18 | 4.17 ± 0.14 | 4.3 ± 0.29 | 3.86 ± 0.06 | 4.13 ± 0.27 |
| Parameter . | 3 mo . | 6 mo . | 9 mo . | |||
|---|---|---|---|---|---|---|
| Control (n = 6) . | KO (n = 6) . | Control (n = 6) . | KO (n = 6) . | Control (n = 6) . | KO (n = 6) . | |
| Heart rate, bpm | 462 ± 40 | 489 ± 65 | 483 ± 54 | 504 ± 70 | 530 ± 27 | 505 ± 39 |
| Right ventricle characteristics | ||||||
| Thickness, mm | 0.23 ± 0.03 | 0.23 ± 0.02 | 0.22 ± 0.04 | 0.25 ± 0.07 | 0.28 ± 0.02 | 0.32 ± 0.03* |
| Diameter, mm | 1.74 ± 0.27 | 1.85 ± 0.1 | 1.46 ± 0.09 | 1.79 ± 0.1* | 1.73 ± 0.05 | 1.90 ± 0.08* |
| Left ventricle characteristics | ||||||
| Thickness IVS, mm | 0.63 ± 0.06 | 0.65 ± 0.06 | 0.65 ± 0.06 | 0.7 ± 0.12 | 0.65 ± 0.12 | 0.80 ± 0.07 |
| Thickness LVPW, mm | 0.74 ± 0.05 | 0.72 ± 0.07 | 0.73 ± 0.06 | 0.69 ± 0.13 | 0.86 ± 0.10 | 0.84 ± 0.14 |
| LVIDd, mm | 3.95 ± 0.2 | 4.07 ± 0.18 | 4.17 ± 0.14 | 4.3 ± 0.29 | 3.86 ± 0.06 | 4.13 ± 0.27 |
Data were obtained using transthoracic echocardiography and represent means ± SEM for 6 mice per group. IVS indicates intraventricular septum; LVPW, left ventricular posterior wall; and LVIDd, left ventricular diastolic dimensions.
Statistically significant (P < .05) vs corresponding control mice.