Table 1 Tdt Mononucleotide insertion... | American Society of Hematology

Table 1

Tdt Mononucleotide insertion bias

Mononucleotide frequencies	A	C	G	T
Out-of-frame insertions*
CD4⁺CD45RO⁻	0.24	0.294	0.247	0.216
CD4⁺CD45RO⁺	0.247	0.284	0.256	0.211
CD8⁺CD45RO⁻	0.25	0.27	0.268	0.209
CD8⁺CD45RO⁺	0.255	0.293	0.24	0.21
In-frame insertions†
CD4⁺CD45RO⁻	0.21	0.285	0.275	0.228
CD4⁺CD45RO⁺	0.216	0.281	0.266	0.235
CD8⁺CD45RO⁻	0.222	0.266	0.288	0.221
CD8⁺CD45RO⁺	0.206	0.294	0.228	0.27

Mononucleotide frequencies	A	C	G	T
Out-of-frame insertions*
CD4⁺CD45RO⁻	0.24	0.294	0.247	0.216
CD4⁺CD45RO⁺	0.247	0.284	0.256	0.211
CD8⁺CD45RO⁻	0.25	0.27	0.268	0.209
CD8⁺CD45RO⁺	0.255	0.293	0.24	0.21
In-frame insertions†
CD4⁺CD45RO⁻	0.21	0.285	0.275	0.228
CD4⁺CD45RO⁺	0.216	0.281	0.266	0.235
CD8⁺CD45RO⁻	0.222	0.266	0.288	0.221
CD8⁺CD45RO⁺	0.206	0.294	0.228	0.27

Mononucleotide frequencies in the inserted junctional nucleotides at the Vβ -Dβ and Dβ -Jβ junctions, computed from the nonproductive, out-of-frame CDR3 sequences, in the CD4⁺CD45RO^+/⁻ and CD8⁺CD45RO^+/⁻ compartments.

†

Mononucleotide frequencies in the inserted junctional nucleotides in the productive, in-frame CDR3 sequences.

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