Comparisons of fibrin clot features in the 3 study groups
| Feature . | VTE patients (n = 100) . | Relatives (n = 100) . | Controls (n = 100) . |
|---|---|---|---|
| Ks, 10−9 cm2 | 6.44 ± 1.01*† | 7.47 ± 1.03* | 9.13 ± 1.12 |
| Compaction, % | 47.9 ± 5.3*† | 53.8 ± 5.6* | 65.2 ± 7.0 |
| Lag phase, seconds | 99 (93-108) | 97 (90-105) | 95 (89-103) |
| ΔAbs (405 nm) | 1.05 (0.94-1.14)* | 1.02 (0.89-1.10)* | 0.94 (0.82-1.05) |
| t50%, min | 9.84 ± 1.02*† | 8.89 ± 0.88* | 7.46 ± 0.82 |
| D-D max, mg/L | 4.29 ± 0.45* | 4.02 ± 0.47 | 3.78 ± 0.41 |
| D-D rate, mg/L/min | 0.075 ± 0.008 | 0.073 ± 0.008 | 0.079 ± 0.008 |
| Feature . | VTE patients (n = 100) . | Relatives (n = 100) . | Controls (n = 100) . |
|---|---|---|---|
| Ks, 10−9 cm2 | 6.44 ± 1.01*† | 7.47 ± 1.03* | 9.13 ± 1.12 |
| Compaction, % | 47.9 ± 5.3*† | 53.8 ± 5.6* | 65.2 ± 7.0 |
| Lag phase, seconds | 99 (93-108) | 97 (90-105) | 95 (89-103) |
| ΔAbs (405 nm) | 1.05 (0.94-1.14)* | 1.02 (0.89-1.10)* | 0.94 (0.82-1.05) |
| t50%, min | 9.84 ± 1.02*† | 8.89 ± 0.88* | 7.46 ± 0.82 |
| D-D max, mg/L | 4.29 ± 0.45* | 4.02 ± 0.47 | 3.78 ± 0.41 |
| D-D rate, mg/L/min | 0.075 ± 0.008 | 0.073 ± 0.008 | 0.079 ± 0.008 |
Values are given as mean ± SD. Ks indicates permeability coefficient; ΔAbs (405 nm), maximum absorbance of fibrin gel at 405 nm determined by using turbidimetry; t50%, half-lysis time; D-D max, maximum D-dimer levels in the lysis assay 2; and D-D rate, maximum rate of increase in D-dimer levels in the lysis assay 2.
P ≤ .001 vs controls.
P < .01 vs relatives.