Multiple linear regression models incorporating patients, relatives, and healthy controls
| Parameter . | Coefficient (95% confidence interval) . | Contribution to variance, percentage . | P . |
|---|---|---|---|
| Clot permeability as dependent variable | |||
| Final model | 36.6 | < .001 | |
| Being a VTE patient | −0.82 (−1.22 to −0.39) | 9.6 | < .001 |
| Fibrinogen | −0.15 (−0.23 to −0.07) | 6.8 | < .001 |
| D-dimer | −1.21 (−2.31 to −0.11) | 4.4 | < .05 |
| CRP | −0.05 (−0.09 to −0.01) | 2.9 | < .05 |
| Being a relative | 0.22 (−0.20 to 0.57) | 0.8 | NS |
| PAI-1 | −0.03 (−0.10 to 0.04) | 0.5 | NS |
| Lysis time t50% as dependent variable | |||
| Final model | 31.1 | < .001 | |
| Being a VTE patient | 0.83 (0.47 to 1.19) | 9.4 | < .001 |
| Fibrinogen | 1.51 (0.68 to 2.39) | 7.5 | < .001 |
| tPA | 0.15 (0.06 to 0.24) | 3.9 | < .005 |
| CRP | 0.08 (0.02 to 0.15) | 1.9 | < .05 |
| PAI-1 | 0.04 (0.02 to 0.07) | 1.2 | < .05 |
| D-dimer | 0.06 (−0.29 to 0.42) | 0.3 | NS |
| Being a relative | 0.01 (−0.05 to 0.07) | 0.1 | NS |
| Parameter . | Coefficient (95% confidence interval) . | Contribution to variance, percentage . | P . |
|---|---|---|---|
| Clot permeability as dependent variable | |||
| Final model | 36.6 | < .001 | |
| Being a VTE patient | −0.82 (−1.22 to −0.39) | 9.6 | < .001 |
| Fibrinogen | −0.15 (−0.23 to −0.07) | 6.8 | < .001 |
| D-dimer | −1.21 (−2.31 to −0.11) | 4.4 | < .05 |
| CRP | −0.05 (−0.09 to −0.01) | 2.9 | < .05 |
| Being a relative | 0.22 (−0.20 to 0.57) | 0.8 | NS |
| PAI-1 | −0.03 (−0.10 to 0.04) | 0.5 | NS |
| Lysis time t50% as dependent variable | |||
| Final model | 31.1 | < .001 | |
| Being a VTE patient | 0.83 (0.47 to 1.19) | 9.4 | < .001 |
| Fibrinogen | 1.51 (0.68 to 2.39) | 7.5 | < .001 |
| tPA | 0.15 (0.06 to 0.24) | 3.9 | < .005 |
| CRP | 0.08 (0.02 to 0.15) | 1.9 | < .05 |
| PAI-1 | 0.04 (0.02 to 0.07) | 1.2 | < .05 |
| D-dimer | 0.06 (−0.29 to 0.42) | 0.3 | NS |
| Being a relative | 0.01 (−0.05 to 0.07) | 0.1 | NS |
NS indicates not significant.