Table 3 Novel TP53 abnormalities... | American Society of Hematology

Table 3

Novel TP53 abnormalities identified in CLL patients with originally intact gene (in investigation I)

Patient	Time between investigations, mo	TP53 defect	Mutation	Therapy before mutation detection	Survival, mo
Patient	Time between investigations, mo	TP53 defect	Mutation	Therapy before mutation detection	From time of abnormality detection	From diagnosis
P1*	33	del/mut	del 1 nt in codon 294	R, CHOP, R-CHOP	1	129
P2	7	del/mut	R273H	CHOP, A, FC	7	28
P3*	51	del/mut	G244D	FCR	2	68
P4	37	del/mut	del 22 nt in intron 5 (splice mutation)	FC	3†	103†
P5*	10	mut/mut	K132R/del 14 nt in codon 194	A	16	85
P6	36	del/mut	T211I	FC, A	3	39
P7	11	wt/mut	I195T	FC, R-CHOP, CHOP, A	27†	48†
P8*	18	del/mut	R175H	FC	16†	102†
P9*	19	wt/mut	C275Y	A	3	148
P10*	19	del/mut	del 9 nt in codon 252	CHOP	32	52
P11*	24	del/mut	ASHM	R-CHOP	37	96
P12*	33	del/2 mut	K120M/del 2 nt in codon 209	FCR	12	92

Patient	Time between investigations, mo	TP53 defect	Mutation	Therapy before mutation detection	Survival, mo
Patient	Time between investigations, mo	TP53 defect	Mutation	Therapy before mutation detection	From time of abnormality detection	From diagnosis
P1*	33	del/mut	del 1 nt in codon 294	R, CHOP, R-CHOP	1	129
P2	7	del/mut	R273H	CHOP, A, FC	7	28
P3*	51	del/mut	G244D	FCR	2	68
P4	37	del/mut	del 22 nt in intron 5 (splice mutation)	FC	3†	103†
P5*	10	mut/mut	K132R/del 14 nt in codon 194	A	16	85
P6	36	del/mut	T211I	FC, A	3	39
P7	11	wt/mut	I195T	FC, R-CHOP, CHOP, A	27†	48†
P8*	18	del/mut	R175H	FC	16†	102†
P9*	19	wt/mut	C275Y	A	3	148
P10*	19	del/mut	del 9 nt in codon 252	CHOP	32	52
P11*	24	del/mut	ASHM	R-CHOP	37	96
P12*	33	del/2 mut	K120M/del 2 nt in codon 209	FCR	12	92

A indicates alemtuzumab; ASHM, aberrant somatic hypermutations in the TP53 gene³⁶; C, cyclophosphamide; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; F, fludarabin; and R, rituximab.

Patient also received therapy before investigation I.

†

Patient is alive.

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