Location of SNPs in coding sequence of mouse Vwf
| Position . | VWF domain . | B6 . | WSB . | Amino acid Δ . |
|---|---|---|---|---|
| 308 | Propeptide | C | T | T103M |
| 365 | Propeptide | G | T | R122L |
| 516 | Propeptide | T | C | — |
| 596 | Propeptide | G | A | R199Q |
| 600 | Propeptide | T | C | — |
| 758 | Propeptide | T | C | I253T |
| 767 | Propeptide | C | T | T256M |
| 774 | Propeptide | T | C | — |
| 1110 | Propeptide | T | C | — |
| 1236 | Propeptide | T | C | — |
| 1404 | Propeptide | T | C | — |
| 1581 | Propeptide | C | T | — |
| 1678 | Propeptide | T | C | S560P |
| 1754 | Propeptide | C | A | A585E |
| 1833 | Propeptide | T | C | — |
| 1852 | Propeptide | A | G | S618G |
| 1965 | Propeptide | C | T | — |
| 2231 | Propeptide | T | C | L744P |
| 2373 | D′ | G | A | — |
| 2487 | D′ | C | T | — |
| 2493 | D′ | T | C | — |
| 2502 | D′ | A | G | — |
| 2583 | D′ | T | C | — |
| 3969 | A1 | T | C | — |
| 4311 | A1 | T | C | — |
| 7148 | B3 | T | C | — |
| 8390 | CK | C | T | — |
| Position . | VWF domain . | B6 . | WSB . | Amino acid Δ . |
|---|---|---|---|---|
| 308 | Propeptide | C | T | T103M |
| 365 | Propeptide | G | T | R122L |
| 516 | Propeptide | T | C | — |
| 596 | Propeptide | G | A | R199Q |
| 600 | Propeptide | T | C | — |
| 758 | Propeptide | T | C | I253T |
| 767 | Propeptide | C | T | T256M |
| 774 | Propeptide | T | C | — |
| 1110 | Propeptide | T | C | — |
| 1236 | Propeptide | T | C | — |
| 1404 | Propeptide | T | C | — |
| 1581 | Propeptide | C | T | — |
| 1678 | Propeptide | T | C | S560P |
| 1754 | Propeptide | C | A | A585E |
| 1833 | Propeptide | T | C | — |
| 1852 | Propeptide | A | G | S618G |
| 1965 | Propeptide | C | T | — |
| 2231 | Propeptide | T | C | L744P |
| 2373 | D′ | G | A | — |
| 2487 | D′ | C | T | — |
| 2493 | D′ | T | C | — |
| 2502 | D′ | A | G | — |
| 2583 | D′ | T | C | — |
| 3969 | A1 | T | C | — |
| 4311 | A1 | T | C | — |
| 7148 | B3 | T | C | — |
| 8390 | CK | C | T | — |
mRNA was isolated from WSB lung and reverse transcribed, and polymerase chain reaction was performed to isolate fragments of Vwf for sequencing. B6 sequence was obtained from NCBI Build 37 of the mouse genome. VWF domains were deduced by comparison to the human amino acid sequence.
— indicates there is no amino acid change caused by a SNP.