Measured activities for first step reagents (125I-BC8-FP or 125I-CC49-FP) and second-step reagent (111In-DOTA-biotin) from target tissues obtained 72 hours after FP administration
| . | BC8-FP . | SD . | CC49-FP . | SD . | DOTA-biotin (BC8-FP) . | SD . | DOTA-Biotin (CC49-FP) . | SD . |
|---|---|---|---|---|---|---|---|---|
| LN | 0.158% | ± 0.01% | 0.020% | ± 0.004% | 0.280% | ± 0.01% | 0.027% | ± 0.01% |
| Spleen | 0.161% | ± 0.01% | 0.045% | ± 0.001% | 0.330% | ± 0.022% | 0.070% | ± 0.002% |
| BM | 0.119% | ± 0.024% | 0.060% | ± 0.013% | 0.175% | ± 0.033% | 0.071% | ± 0.016% |
| . | BC8-FP . | SD . | CC49-FP . | SD . | DOTA-biotin (BC8-FP) . | SD . | DOTA-Biotin (CC49-FP) . | SD . |
|---|---|---|---|---|---|---|---|---|
| LN | 0.158% | ± 0.01% | 0.020% | ± 0.004% | 0.280% | ± 0.01% | 0.027% | ± 0.01% |
| Spleen | 0.161% | ± 0.01% | 0.045% | ± 0.001% | 0.330% | ± 0.022% | 0.070% | ± 0.002% |
| BM | 0.119% | ± 0.024% | 0.060% | ± 0.013% | 0.175% | ± 0.033% | 0.071% | ± 0.016% |
Animals received 16.9 nmol/kg of either 125I-BC8-FP or 125I-CC49-FP followed 24 hours later by 1.2 mg/m2 of 111In-DOTA-biotin. The contents of the trace-labeled reagents in tissue specimens were measured in a dual-channel gamma counter and are expressed as the percentage injected dose per gram of tissue (%ID/g). SDs reflect 3 biopsy specimens from each tissue.