Nox inhibitor, apocynin, decreases MK polyploidy
| Ploidy . | Control . | 200 μM apocynin . | P . |
|---|---|---|---|
| 2n | 12.94 ± 2.84 | 14.39 ± 1.31 | .468 |
| 4n | 8.14 ± 1.13 | 8.56 ± 0.51 | .591 |
| 8n | 6.39 ± 0.15 | 13.95 ± 1.22 | < .001 |
| 16n | 18.80 ± 1.19 | 29.83 ± 1.02 | < .001 |
| 32n | 20.13 ± 1.67 | 12.72 ± 0.76 | .002 |
| 64n | 17.45 ± 2.61 | 1.24 ± 0.29 | < .001 |
| Ploidy . | Control . | 200 μM apocynin . | P . |
|---|---|---|---|
| 2n | 12.94 ± 2.84 | 14.39 ± 1.31 | .468 |
| 4n | 8.14 ± 1.13 | 8.56 ± 0.51 | .591 |
| 8n | 6.39 ± 0.15 | 13.95 ± 1.22 | < .001 |
| 16n | 18.80 ± 1.19 | 29.83 ± 1.02 | < .001 |
| 32n | 20.13 ± 1.67 | 12.72 ± 0.76 | .002 |
| 64n | 17.45 ± 2.61 | 1.24 ± 0.29 | < .001 |
Summary of MK ploidy status in apocynin-treated BM cultures expressed as a percentage ± SD of total MKs collected (summary of 3 independent experiments). Subgroups were compared with the t test.