Association of RUNX1 mutation with other genetic mutations
| Variable . | Whole cohort, n = 470 . | RUNX1-mutated patients, n = 62 . | RUNX1-wild patients, n = 408 . | P . |
|---|---|---|---|---|
| CEBPA | 66 (14.0) | 2 (3.2) | 64 (15.7) | > .006 |
| FLT3/ITD | 110 (23.4) | 14 (22.6) | 96 (23.5) | > .999 |
| FLT3/TKD | 33 (7.0) | 6 (9.7) | 27 (6.6) | = .380 |
| N-RAS | 54 (11.5) | 5 (8.1) | 49 (12.0) | = .520 |
| K-RAS | 16 (3.4) | 2 (3.2) | 14 (3.4) | > .999 |
| PTPN11 | 21 (4.5) | 4 (6.5) | 17 (4.2) | > .504 |
| JAK2 | 4 (0.8) | 0 (0.0) | 4 (0.9) | > .999 |
| NPM1 | 106 (22.6) | 3 (4.8) | 103 (25.2) | < .001 |
| MLL/PTD | 28 (6.0) | 9 (14.5) | 19 (4.7) | = .006 |
| KIT | 14 (3.0) | 0 (0.0) | 14 (3.4) | .233 |
| WTI | 32 (6.8) | 2 (3.2) | 30 (7.4) | = .290 |
| Variable . | Whole cohort, n = 470 . | RUNX1-mutated patients, n = 62 . | RUNX1-wild patients, n = 408 . | P . |
|---|---|---|---|---|
| CEBPA | 66 (14.0) | 2 (3.2) | 64 (15.7) | > .006 |
| FLT3/ITD | 110 (23.4) | 14 (22.6) | 96 (23.5) | > .999 |
| FLT3/TKD | 33 (7.0) | 6 (9.7) | 27 (6.6) | = .380 |
| N-RAS | 54 (11.5) | 5 (8.1) | 49 (12.0) | = .520 |
| K-RAS | 16 (3.4) | 2 (3.2) | 14 (3.4) | > .999 |
| PTPN11 | 21 (4.5) | 4 (6.5) | 17 (4.2) | > .504 |
| JAK2 | 4 (0.8) | 0 (0.0) | 4 (0.9) | > .999 |
| NPM1 | 106 (22.6) | 3 (4.8) | 103 (25.2) | < .001 |
| MLL/PTD | 28 (6.0) | 9 (14.5) | 19 (4.7) | = .006 |
| KIT | 14 (3.0) | 0 (0.0) | 14 (3.4) | .233 |
| WTI | 32 (6.8) | 2 (3.2) | 30 (7.4) | = .290 |
Values are no. (%) of patients with alteration.