Table 2 Biologic function and list of... | American Society of Hematology

Table 2

Biologic function and list of immune system genes that had a consistent 2-fold difference in expression after rFVIII treatment relative to the HBSS-treated mice

Functional grouping: gene function	Gene name	Gene symbol	Intensity ratio (rFVIII/HBSS)
Cell-matrix adhesion: increases cell survival¹²	Connective tissue growth factor	Ctgf	0.44
Host immune defense to bacteria: induces Th1 responses¹³	Cathelicidin antimicrobial peptide	Camp	3.22
Surface marker: proinflammatory cytokines increasing phagocytoses¹⁴	S100 calcium binding protein A8	S100a8	2.5
Host defense to bacteria: inhibits actions of TNF-α¹⁵	Proteoglycan 2	Prg2	0.36
Oxidative stress: prevents inflammation¹⁶	Glutathione peroxidase 2	Gpx2	2.44
Host defense to bacteria: Th1-polarized Ag-specific immune responses¹⁷	Lactotransferrin	Ltf	2.27

Functional grouping: gene function	Gene name	Gene symbol	Intensity ratio (rFVIII/HBSS)
Cell-matrix adhesion: increases cell survival¹²	Connective tissue growth factor	Ctgf	0.44
Host immune defense to bacteria: induces Th1 responses¹³	Cathelicidin antimicrobial peptide	Camp	3.22
Surface marker: proinflammatory cytokines increasing phagocytoses¹⁴	S100 calcium binding protein A8	S100a8	2.5
Host defense to bacteria: inhibits actions of TNF-α¹⁵	Proteoglycan 2	Prg2	0.36
Oxidative stress: prevents inflammation¹⁶	Glutathione peroxidase 2	Gpx2	2.44
Host defense to bacteria: Th1-polarized Ag-specific immune responses¹⁷	Lactotransferrin	Ltf	2.27

Genes that had at least a 2-fold change in expression after rFVIII or pdFVIII infusion, respectively; all gene expression ratios are relative to HBSS-infused mice.

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